Dambska M, Laure-Kamionowska M, Liebhart M
Clin Neuropathol. 1987 May-Jun;6(3):110-5.
We present a neuropathological study of brainstem involvement during the neonatal period, under the influence of prolonged fetal asphyxia. The investigation was performed on 20 brains of premature and mature newborns, who died in the course of chronic asphyxia. Ischemic cell change, neuronal loss and gliosis were present in the brainstem of all infants. Two topographic patterns of brainstem lesions in chronic anoxic encephalopathy were distinguishable in the newborns. The neurons of the cranial nerve nuclei were more severely damaged in the group of premature newborns. More severe lesions of the reticular formation were found in the group of mature newborns. The topography of brainstem damage seems to be dependent on the maturity of CNS structures at the time of injury.
我们呈现了一项关于新生儿期在长时间胎儿窒息影响下脑干受累情况的神经病理学研究。该研究对20例因慢性窒息死亡的早产和足月新生儿的大脑进行。所有婴儿的脑干均出现缺血性细胞改变、神经元丢失和胶质细胞增生。在新生儿慢性缺氧性脑病中，脑干病变存在两种拓扑学模式。早产新生儿组中脑神经核的神经元受损更严重。足月新生儿组中网状结构的损伤更严重。脑干损伤的拓扑学情况似乎取决于损伤时中枢神经系统结构的成熟度。
