Regensburg Center for Biochemistry, Biochemistry III - Institute for Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany.
RNA Biol. 2022 Jan;19(1):1045-1049. doi: 10.1080/15476286.2022.2121421.
Thanks to genetics, biochemistry, and structural biology many features of the ribosome´s life cycles in models of bacteria, eukaryotes, and some organelles have been revealed to near-atomic details. Collectively, these studies have provided a very detailed understanding of what are now well-established prototypes for ribosome biogenesis and function as viewed from a 'classical' model organisms perspective. However, very important challenges remain ahead to explore the functional and structural diversity of both ribosome biogenesis and function across the biological diversity on earth. Particularly, the 'third domain of life', the archaea, and also many non-model bacterial and eukaryotic organisms have been comparatively neglected. Importantly, characterizing these additional biological systems will not only offer a yet untapped window to enlighten the evolution of ribosome biogenesis and function but will also help to unravel fundamental principles of molecular adaptation of these central cellular processes.
得益于遗传学、生物化学和结构生物学的发展，在细菌、真核生物和一些细胞器的模型中，核糖体的生命周期的许多特征已经被揭示到近原子的细节。总的来说，这些研究为核糖体生物发生和功能提供了一个非常详细的理解，从“经典”模式生物的角度来看，这些都是现在已经确立的原型。然而，要探索地球上生物多样性的核糖体生物发生和功能的功能和结构多样性，仍然面临着非常重要的挑战。特别是“生命的第三领域”——古菌，以及许多非模式细菌和真核生物，相对来说被忽视了。重要的是，对这些额外的生物系统进行特征描述不仅将提供一个尚未开发的窗口，以阐明核糖体生物发生和功能的进化，还将有助于揭示这些核心细胞过程分子适应的基本原理。
