Londei Paola, Ferreira-Cerca Sébastien
Department of Molecular Medicine, University of Rome Sapienza, Rome, Italy.
Biochemistry III - Regensburg Center for Biochemistry, Institute for Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany.
Front Microbiol. 2021 Jul 22;12:686977. doi: 10.3389/fmicb.2021.686977. eCollection 2021.
Making ribosomes is a major cellular process essential for the maintenance of functional ribosome homeostasis and to ensure appropriate gene expression. Strikingly, although ribosomes are universally conserved ribonucleoprotein complexes decoding the genetic information contained in messenger RNAs into proteins, their biogenesis shows an intriguing degree of variability across the tree of life. In this review, we summarize our knowledge on the least understood ribosome biogenesis pathway: the archaeal one. Furthermore, we highlight some evolutionary conserved and divergent molecular features of making ribosomes across the tree of life.
核糖体的生成是细胞的一项主要过程,对于维持功能性核糖体稳态以及确保适当的基因表达至关重要。引人注目的是,尽管核糖体是普遍保守的核糖核蛋白复合体,可将信使核糖核酸中包含的遗传信息解码为蛋白质,但其生物发生在整个生命之树上呈现出令人感兴趣的可变程度。在这篇综述中,我们总结了我们对了解最少的核糖体生物发生途径——古菌核糖体生物发生途径的认识。此外,我们强调了整个生命之树上核糖体生成过程中一些进化上保守和不同的分子特征。