Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
World J Biol Psychiatry. 2023 Jun;24(5):387-399. doi: 10.1080/15622975.2022.2112974. Epub 2022 Sep 9.
Disrupted auditory networks play an important role in the pathophysiology of psychosis, with abnormalities already observed in individuals at clinical high-risk for psychosis (CHR). Here, we examine structural and functional connectivity of an auditory network in CHR utilising state-of-the-art electroencephalography and diffusion imaging techniques.
Twenty-six CHR subjects and 13 healthy controls (HC) underwent diffusion MRI and electroencephalography while performing an auditory task. We investigated structural connectivity, measured as fractional anisotropy in the Arcuate Fasciculus (AF), Cingulum Bundle, and Superior Longitudinal Fasciculus-II. Gamma-band lagged-phase synchronisation, a functional connectivity measure, was calculated between cortical regions connected by these tracts.
CHR subjects showed significantly higher structural connectivity in the right AF than HC ( < .001). Although non-significant, functional connectivity between cortical areas connected by the AF was lower in CHR than HC ( = .078). Structural and functional connectivity were correlated in HC ( = .056) but not in CHR ( = .29).
We observe significant differences in structural connectivity of the AF, without a concomitant significant change in functional connectivity in CHR subjects. This may suggest that the CHR state is characterised by a decoupling of structural and functional connectivity, possibly due to abnormal white matter maturation.
听觉网络紊乱在精神分裂症的病理生理学中起着重要作用，在处于精神病高危状态（CHR）的个体中已经观察到异常。在这里，我们利用最先进的脑电图和弥散成像技术研究 CHR 中的听觉网络的结构和功能连接。
26 名 CHR 受试者和 13 名健康对照（HC）在执行听觉任务时接受了弥散 MRI 和脑电图检查。我们研究了结构连接，以弓状束（AF）、扣带束和上纵束-II 的分数各向异性来衡量。计算了这些束连接的皮质区域之间的伽马波段滞后相位同步性，这是一种功能连接测量方法。
CHR 受试者的右侧 AF 结构连接明显高于 HC（ <.001）。尽管没有统计学意义，但 CHR 的 AF 连接的皮质区域之间的功能连接低于 HC（ =.078）。HC 中的结构和功能连接具有相关性（ =.056），但 CHR 中没有相关性（ =.29）。
我们观察到 CHR 受试者的 AF 结构连接存在显著差异，但功能连接没有明显变化。这可能表明 CHR 状态的特征是结构和功能连接的分离，可能是由于白质成熟异常所致。
