Wang Feifu, Vincent Stephen J, Cho Pauline, Shen Yi, Sheng Zihao, Shen Meixiao, Jiang Jun
National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Optometry and Vision Science, Centre for Vision and Eye Research, Queensland University of Technology, Brisbane, QLD, Australia.
Eye Vis (Lond). 2025 Jul 14;12(1):27. doi: 10.1186/s40662-025-00443-3.
To analyze the fluid reservoir thickness over the whole cornea during scleral lens settling using wide-angle optical coherence tomography (OCT) images and customized computer software.
A total of 75 participants were recruited - 29 (myopes) with regular corneas and 46 with irregular corneas (35 with keratoconus, and 11 post-keratoplasty). All participants were fitted with customized scleral lenses and anterior segment OCT (Tomey Casia 2) images were taken 0, 30, 60, 120, and 240 min after lens application at the dispensing visit. Customized software was used to automatically segment the anterior cornea and the posterior surface of the scleral lens and determine the fluid reservoir thickness at 17 corneal regions across a 12 mm diameter.
Fluid reservoir thickness decreased over time (P < 0.001) following an exponential decay, with no differences observed over time between the three groups (P = 0.97). The reduction in fluid reservoir thickness over four hours varied slightly between the central (149 ± 9 μm), mid-peripheral (139 ± 11 μm), and peripheral regions (131 ± 15 μm), P = 0.046. The fluid reservoir was thinnest in the superior mid-periphery for both the myopia and post-keratoplasty groups, and centrally for the keratoconus group. The fluid reservoir was thickest inferiorly for all groups, with the greatest level of asymmetry observed along the vertical meridian.
Fluid reservoir thickness decreased most rapidly during the first two hours of lens wear and followed an exponential decay for both regular and irregular corneas across all corneal locations. Fluid reservoir asymmetry was greatest along the vertical meridian with a thicker reservoir observed in the inferior corneal regions.
使用广角光学相干断层扫描（OCT）图像和定制的计算机软件，分析巩膜镜沉降过程中整个角膜上的液池厚度。
共招募了75名参与者——29名角膜规则的近视患者和46名角膜不规则的患者（35名圆锥角膜患者和11名角膜移植术后患者）。所有参与者均佩戴定制的巩膜镜，并在配镜就诊时于佩戴镜片后0、30、60、120和240分钟拍摄眼前节OCT（Tomey Casia 2）图像。使用定制软件自动分割前角膜和巩膜镜后表面，并确定直径12毫米的17个角膜区域的液池厚度。
液池厚度随时间呈指数衰减而降低（P < 0.001），三组之间随时间未观察到差异（P = 0.97）。四小时内液池厚度的减少在中央（149±9μm）、中周边（139±11μm）和周边区域（131±15μm）之间略有不同，P = 0.046。近视组和角膜移植术后组的液池在中周边上方最薄，圆锥角膜组在中央最薄。所有组的液池在下方最厚，沿垂直子午线观察到最大程度的不对称。
在佩戴镜片的前两小时内，液池厚度下降最快，对于规则和不规则角膜的所有角膜位置，液池厚度均呈指数衰减。液池不对称沿垂直子午线最大，在角膜下方区域观察到较厚的液池。
