Gokmen Onur, Ozgur Gokhan
Department of Ophthalmology, 53000Yuzuncu Yıl University, Faculty of Medicine, Van, Turkey.
Department of Ophthalmology Samsun, Health Sciences University Samsun Training and Research Hospital, Samsun, Turkey.
Eur J Ophthalmol. 2023 Jan;33(1):455-462. doi: 10.1177/11206721221124650. Epub 2022 Sep 9.
To examine the effects of chronic smoking on vascular density in superficial and deep retinal vascular plexuses and choroidal thicknesses.
Superficial and deep vessel densities and choroidal thicknesses of smoking volunteers and healthy non-smoking volunteers were measured with the Topcon DRI OCT-1 Tritron® device and compared with each other.
This study included 108 eyes of 54 smoking volunteers and 108 eyes of 54 healthy volunteers as a control group. The average superficial vascular density index and deep vascular density indexes of smokers were found to be 39.81 ± 1.5% and 42.53 ± 1.9%, respectively (P = 0.53), while the non-smoking control group was 40.09 ± 1.3% and 41.57 ± 1.6%, respectively (P = 0.006). Average choroidal thicknesses were 284.22 ± 59 in smokers and 270.72 ± 61 in the control group (P = 0.247). Also, smoking quantity per day x years was found to be significantly negatively correlated with average choroidal thicknesses. (P = 0,011).
In this study, it was determined that chronic smoking increases deep retinal vascular densities on retinal vascular plexus. However, the cumulative effect of smoking was found to be negatively correlated with choroidal thicknesses. Smoking has microvascular effects on vessels such as vasodilatation, vasoconstriction, increased platelet aggregation, endothelial dysfunction. However, studies in the literature are in dispute with the effects of smoking on choroidal and retinal vessels. This study may show that chronic smoking may have different vascular effects on the superficial and deep plexuses and choroidal vessels, as well as different effects from acute use.
研究长期吸烟对视网膜浅、深血管丛血管密度及脉络膜厚度的影响。
使用拓普康DRI OCT-1 Tritron®设备测量吸烟志愿者和健康非吸烟志愿者的视网膜浅、深血管密度及脉络膜厚度，并进行对比。
本研究纳入54名吸烟志愿者的108只眼作为实验组，54名健康志愿者的108只眼作为对照组。吸烟者的视网膜浅血管密度指数和深血管密度指数平均分别为39.81±1.5%和42.53±1.9%（P = 0.53），而非吸烟对照组分别为40.09±1.3%和41.57±1.6%（P = 0.006）。吸烟者的脉络膜平均厚度为284.22±59，对照组为270.72±61（P = 0.247）。此外，发现每日吸烟量×吸烟年数与脉络膜平均厚度呈显著负相关（P = 0.011）。
本研究确定长期吸烟会增加视网膜血管丛的深层视网膜血管密度。然而，发现吸烟的累积效应与脉络膜厚度呈负相关。吸烟对血管有微血管效应，如血管舒张、血管收缩、血小板聚集增加、内皮功能障碍。然而，文献中的研究对于吸烟对脉络膜和视网膜血管的影响存在争议。本研究可能表明，长期吸烟可能对视网膜浅、深血管丛及脉络膜血管产生不同的血管效应，以及与急性吸烟不同的影响。
