酒渣鼻患者血清肿瘤坏死因子样弱凋亡诱导因子、肿瘤坏死因子相关凋亡诱导配体及氧化应激标志物的评估
Evaluation of serum TWEAK, TRAIL, and oxidative stress markers in rosacea patients.
作者信息
Durmaz Imge, Turkmen Dursun, Altunisik Nihal, Uremis Nuray, Uremis Muhammed Mehdi, Sener Serpil, Turkoz Yusuf
机构信息
Department of Dermatology, Inonu University, Malatya, Turkey.
Department of Medical Biochemistry, Inonu University, Malatya, Turkey.
出版信息
J Cosmet Dermatol. 2022 Dec;21(12):7050-7055. doi: 10.1111/jocd.15365. Epub 2022 Sep 29.
BACKGROUND
Rosacea is a chronic inflammatory skin disease of unknown pathogenesis. TWEAK and TRAIL are two cytokines thought to have a role in the pathogenesis of some inflammatory and autoimmune diseases.
AIMS
The purpose of this study was to examine TWEAK and TRAIL serum levels and oxidative stress markers in patients with rosacea.
MATERIAL AND METHOD
Forty rosacea patients and 40 sex- and age-matched healthy controls were involved in the study. Serum TWEAK and TRAIL levels were evaluated with ELISA kits. Serum total antioxidant status, total oxidant status, total thiol, native thiol, disulfide levels were evaluated, and oxidative stress index was computed.
RESULTS
Serum levels of TWEAK, TRAIL, and oxidative stress markers did not differ statistically in the patients and controls. Both TWEAK and TRAIL levels in the patients were detected to be statistically higher in male than in female.
CONCLUSION
TWEAK and TRAIL may not have a systemic effect in rosacea, unlike other inflammatory diseases. More studies are needed to investigate the role of TWEAK and TRAIL in rosacea.
背景
酒渣鼻是一种发病机制不明的慢性炎症性皮肤病。肿瘤坏死因子样弱凋亡诱导因子（TWEAK）和肿瘤坏死因子相关凋亡诱导配体（TRAIL）是两种被认为在某些炎症性和自身免疫性疾病发病机制中起作用的细胞因子。
目的
本研究旨在检测酒渣鼻患者血清中TWEAK和TRAIL水平以及氧化应激标志物。
材料与方法
本研究纳入40例酒渣鼻患者和40例年龄、性别匹配的健康对照。采用酶联免疫吸附测定（ELISA）试剂盒评估血清TWEAK和TRAIL水平。评估血清总抗氧化状态、总氧化状态、总巯基、天然巯基、二硫键水平，并计算氧化应激指数。
结果
患者和对照组血清中TWEAK、TRAIL和氧化应激标志物水平无统计学差异。患者中，男性的TWEAK和TRAIL水平在统计学上均高于女性。
结论
与其他炎症性疾病不同，TWEAK和TRAIL可能对酒渣鼻没有全身影响。需要更多研究来探讨TWEAK和TRAIL在酒渣鼻发病机制中的作用。
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