Hospital Israelita Albert Einstein, São Paulo- SP, Brazil.
Universidade Nove de Julho (UNINOVE), São Paulo- SP, Brazil.
PLoS One. 2022 Sep 9;17(9):e0273051. doi: 10.1371/journal.pone.0273051. eCollection 2022.
The risk of malnutrition is an important predictor of functional capacity in the elderly population. However, whether malnutrition is associated with functional capacity in patients with peripheral artery disease (PAD) is poorly known.
To analyse the association between the risk of malnutrition and functional capacity in patients with PAD.
This cross-sectional study included 135 patients with PAD of both genders, ≥50 years old, with symptomatic PAD (Rutherford stage I to III) in one or both limbs and with ankle-brachial index ≤0.90. The risk of malnutrition was assessed by the short form of the Mini Nutritional Assessment-Short Form and patients were classified as having normal nutritional status (n = 92) and at risk of malnutrition (n = 43). Functional capacity was objectively assessed using the six-minute walking test (6MWT, absolute maximal distance and relativized and expressed as a percentage of health subjects), short-physical performance battery (SPPB, balance, gait speed and the sit and stand test) and the handgrip test, and subjectively, using the Walking Impairment Questionnaire and Walking Estimated-Limitation Calculated by History. The association between the risk of malnutrition and functional capacity was analysed using bivariate and multivariate logistic regression adjustments for gender, age, ankle-brachial index, body mass index, use of statins, coronary arterial disease and stroke. For all statistical analyses, significance was accepted at p<0.05.
Thirty-two per cent of our patients were classified with a risk of malnutrition. The risk of malnutrition was associated with the absolute 6MWT total distance (OR = 0.994, P = 0.031) relative 6MWT total distance (OR = 0.971, P = 0.038), lowest SPPB total score (OR = 0.682, P = 0.011), sit and stand (OR = 1.173, P = 0.003) and usual 4-meter walk test (OR = 1.757, P = 0.034).
In patients with PAD, the risk of malnutrition was associated with objective measurements of functional capacity.
营养不良的风险是老年人功能能力的一个重要预测因素。然而，营养不良是否与外周动脉疾病（PAD）患者的功能能力相关尚不清楚。
分析 PAD 患者的营养不良风险与功能能力之间的关系。
这项横断面研究纳入了 135 名年龄均≥50 岁的性别不限的 PAD 患者，这些患者有单侧或双侧肢体的症状性 PAD（Rutherford 分期 I 至 III 期）和踝肱指数≤0.90。采用 Mini Nutritional Assessment-Short Form 的简表评估营养不良风险，将患者分为营养状况正常（n=92）和有营养不良风险（n=43）。采用 6 分钟步行试验（6MWT，绝对最大距离和相对化并表示为健康受试者的百分比）、短体适能电池（SPPB，平衡、步态速度和坐站测试）和握力测试客观评估功能能力，并用步行障碍问卷和基于病史的步行估计受限计算主观评估。采用二元和多元逻辑回归调整性别、年龄、踝肱指数、体重指数、他汀类药物使用、冠状动脉疾病和中风，分析营养不良风险与功能能力之间的关系。所有统计分析均以 p<0.05 为显著性水平。
我们的患者中有 32%被归类为有营养不良风险。营养不良风险与 6MWT 绝对总距离（OR=0.994，P=0.031）、相对 6MWT 总距离（OR=0.971，P=0.038）、最低 SPPB 总评分（OR=0.682，P=0.011）、坐站（OR=1.173，P=0.003）和通常的 4 米步行测试（OR=1.757，P=0.034）相关。
在 PAD 患者中，营养不良风险与功能能力的客观测量相关。
