Postgraduate Program in Medicine, Nove de Julho University, São Paulo, SP, Brazil.
Albert Einstein Israeli Teaching and Research Institute, São Paulo, SP, Brazil.
J Vasc Nurs. 2024 Jun;42(2):105-109. doi: 10.1016/j.jvn.2024.02.002. Epub 2024 Feb 24.
The six-minute walk test (6MWT) is extensively employed to evaluate gait impairment in patients with symptomatic peripheral artery disease (PAD) and has been associated with different health outcomes. However, various approaches exist for calculating and interpreting the six-minute test in order to address the needs of patients more effectively. Therefore, we investigated how these different approaches correlate with functional capacity and cardiovascular health in patients with symptomatic PAD.
In total, 227 PAD patients [65.2% men and 67 (13) y.o.] were included in this cross-sectional study. The 6MWT was performed along a 30-meter corridor and the distance was expressed in three ways: absolute (described as the meters walked during the test), relativized (based on the results of the 6MWT in healthy individuals), and DW (multiplying the body weight in kilograms by the absolute distance in the 6MWT). A functional capacity z-score was calculated using the results of the handgrip strength test, 4-meter walking test, and sit-and-stand test. A cardiovascular parameter z-score was calculated with data on brachial and central blood pressure, the low-frequency component/high-frequency component ratio, and carotid-femoral pulse wave velocity.
The absolute (b = 0.30, 95%CI: 18-0.43, R² = 0.11, p < 0.001) and DW (b = 0.40, 95%CI: 27-0.53, R² = 0.17, p < 0.001) measures were related to functional capacity, independently of sex, age, and the ankle-arm index of the patients. Neither absolute nor DW were related to cardiovascular health. The relativized measure was not associated with either functional capacity or cardiovascular health.
In patients with symptomatic PAD, absolute and DW measures are related to functional capacity, but not cardiovascular function.
六分钟步行试验（6MWT）广泛用于评估有症状外周动脉疾病（PAD）患者的步态障碍，并与不同的健康结果相关。然而，为了更有效地满足患者的需求，存在多种计算和解释六分钟测试的方法。因此，我们研究了这些不同的方法与有症状 PAD 患者的功能能力和心血管健康的相关性。
共有 227 名 PAD 患者（65.2%为男性，67（13）岁）参与了这项横断面研究。6MWT 在 30 米走廊上进行，距离以三种方式表示：绝对（描述为测试期间行走的米数）、相对（基于健康个体的 6MWT 结果）和 DW（将体重乘以 6MWT 中的绝对距离）。使用握力测试、4 米步行测试和坐站测试的结果计算功能能力 z 评分。使用肱动脉和中心血压、低频成分/高频成分比值以及颈股脉搏波速度的数据计算心血管参数 z 评分。
绝对（b = 0.30，95%CI：18-0.43，R² = 0.11，p < 0.001）和 DW（b = 0.40，95%CI：27-0.53，R² = 0.17，p < 0.001）与功能能力相关，独立于患者的性别、年龄和踝臂指数。绝对和 DW 均与心血管健康无关。相对测量与功能能力或心血管健康均无关。
在有症状的 PAD 患者中，绝对和 DW 测量与功能能力相关，但与心血管功能无关。
