Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Wojska Polskiego 31, Poznań, 60-624, Poland.
Pennsylvania State University, Department of Kinesiology, Women's Health and Exercise Laboratory, University Park, PA16802, USA.
Appl Physiol Nutr Metab. 2022 Nov 1;47(11):1085-1095. doi: 10.1139/apnm-2021-0789. Epub 2022 Sep 9.
Diet plays a role in the pathophysiology and treatment of women with hyperandrogenic menstrual disturbances; however, limited research exists examining components of dietary intake in women with subclinical menstrual disturbances. The aim of this investigation was to evaluate the relationship between diet quality and hormonal status in exercising women with menstrual disturbances. Eighty exercising women with ovulatory menstrual cycles (OV; = 32), women with oligo/amenorrhea without evidence of hyperandrogenism (Oligo/Amen-LowFAI; = 28), and women with oligo/amenorrhea and evidence of subclinical hyperandrogenism (Oligo/Amen-HighFAI; = 32) participated in the cross-sectional observational study (Clinical Trial Number: NCT00392873). Self-reported menstrual history, resting energy expenditure, body composition, hormonal and metabolic hormone concentrations determined reproductive and metabolic status. Serum androgens and calculated free androgen index (FAI) determined androgen status. The Diet Quality Index International (DQI-I) and the Dietary Inflammatory Index (DII) evaluated quality of diet. Oligo/Amen-HighFAI group had the highest androgen concentrations ( < 0.05) and lower DQI-I score compared to OV group and Oligo/Amen-LowFAI ( < 0.05). The Oligo/Amen-HighFAI group consumed less of vitamin A, B, B, B, magnesium, and potassium compared to the Oligo/Amen-LowFAI group (all < 0.05). In the women with menstrual disturbances with subclinically elevated androgens, poor diet quality is related to altered hormonal parameters which may have implications for future nutritional treatment strategies.
饮食在患有高雄激素血症月经紊乱的女性的病理生理学和治疗中起作用；然而，关于亚临床月经紊乱女性饮食摄入成分的研究有限。本研究旨在评估饮食质量与运动女性月经紊乱患者激素状态之间的关系。 80 名运动的月经周期正常的女性（OV；=32）、无高雄激素血症证据的寡/闭经女性（Oligo/Amen-LowFAI；=28）和有亚临床高雄激素血症的寡/闭经女性（Oligo/Amen-HighFAI；=32）参与了横断面观察性研究（临床试验编号：NCT00392873）。自我报告的月经史、静息能量消耗、身体成分、激素和代谢激素浓度确定了生殖和代谢状态。血清雄激素和计算的游离雄激素指数（FAI）确定了雄激素状态。膳食质量指数国际（DQI-I）和膳食炎症指数（DII）评估了饮食质量。与 OV 组和 Oligo/Amen-LowFAI 组相比，Oligo/Amen-HighFAI 组的雄激素浓度最高（<0.05），DQI-I 评分较低（<0.05）。与 Oligo/Amen-LowFAI 组相比，Oligo/Amen-HighFAI 组的维生素 A、B、B、B、镁和钾摄入量较少（均<0.05）。在亚临床高雄激素血症的月经紊乱女性中，较差的饮食质量与激素参数改变有关，这可能对未来的营养治疗策略有影响。
