药用植物小蔓长春花（Centipeda minima（L.）A. Braun & Asch.）中活性化合物具有良好的抗癌活性和作用机制。

Promising anticancer activities and mechanisms of action of active compounds from the medicinal herb Centipeda minima (L.) A. Braun & Asch.

机构信息

Key Laboratory of Chinese Medicinal Resource from Lingnan (Guangzhou University of Chinese Medicine), Ministry of Education; Research Center of Chinese Herbal Resources Science and Engineering, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; Dongguan Institute of Guangzhou University of Chinese Medicine, Dongguan 523808, China.

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

出版信息

Phytomedicine. 2022 Nov;106:154397. doi: 10.1016/j.phymed.2022.154397. Epub 2022 Aug 19.

DOI:10.1016/j.phymed.2022.154397

PMID:36084403

Abstract

BACKGROUND

Centipeda minima (L.) A. Braun & Asch (C. minima) has been used as a traditional Chinese herbal medicine to treat multiple diseases, including sinusitis, rhinitis, headache, and allergy. To date, the anticancer properties of C. minima have drawn considerable attention owing to the anticancer potential of C. minima extracts, the identification of active components, and the elucidation of underlying molecular mechanisms. However, the anticancer properties and significance of active components in C. minima have rarely been summarized.

PURPOSE

This review presents a comprehensive summary of the anticancer properties exhibited by active components of C. minima.

METHODS

An extensive search for published articles on the anticancer activities and active components of C. minima was performed using Web of Science, PubMed, Science Direct, and Google Scholar.

RESULTS

C. minima extracts exhibited both anticancer and chemosensitizing effects. Phytochemical studies have identified the active anticancer components of C. minima extracts. Sesquiterpene lactones, such as 6-O-angeloylplenolin (6-OAP, or brevilin A) and arnicolide D, have similar structures and anticancer mechanisms. As the most abundant sesquiterpene lactone in C. minima, 6-OAP exhibits anticancer activities mainly by targeting Skp1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase and signal transducers and activators of transcription 3 (STAT3). Clinical trials have assessed the potential of 6-OAP in patients with vertex balding and alopecia areata, given its effect on JAK-STATs signaling. Chlorogenic acid, a representative organic acid in C. minima, reportedly possesses anticancer potential and inhibits tumor growth by affecting tumor microenvironment and has been approved for phase II clinical trials in patients with glioma in China.

CONCLUSION

In the present review, we highlight intriguing anticancer properties mediated by active compounds isolated from C. minima extracts, particularly sesquiterpene lactones, which might provide clues for developing novel anticancer drugs. Relevant clinical trials on chlorogenic acid and 6-OAP can promote anticancer clinical applications. Therefore, it is worth comprehensively elucidating underlying anticancer mechanisms and conducting clinical trials on C. minima and its active components.

摘要

背景

鸡矢藤（C. minima）作为一种传统的中草药，已被用于治疗多种疾病，包括鼻窦炎、鼻炎、头痛和过敏。迄今为止，由于鸡矢藤提取物的抗癌潜力、活性成分的鉴定以及潜在分子机制的阐明，鸡矢藤的抗癌特性引起了相当大的关注。然而，鸡矢藤的抗癌特性和活性成分的意义很少被总结。

目的

本综述全面总结了鸡矢藤活性成分的抗癌特性。

方法

通过 Web of Science、PubMed、Science Direct 和 Google Scholar 广泛搜索关于鸡矢藤抗癌活性和活性成分的已发表文章。

结果

鸡矢藤提取物具有抗癌和化疗增敏作用。植物化学研究已经确定了鸡矢藤提取物的活性抗癌成分。倍半萜内酯，如 6-O-当归酰基大根香叶烯（6-OAP，或大根香叶烯 A）和arnicolide D，具有相似的结构和抗癌机制。作为鸡矢藤中最丰富的倍半萜内酯，6-OAP 主要通过靶向 Skp1-Cullin1-F-box 蛋白（SCF）E3 泛素连接酶和信号转导和转录激活因子 3（STAT3）发挥抗癌活性。临床试验评估了 6-OAP 在患有顶点秃发和斑秃患者中的潜在应用，因为它对 JAK-STATs 信号的影响。鸡矢藤中的代表性有机酸绿原酸，据报道具有抗癌潜力，通过影响肿瘤微环境抑制肿瘤生长，并已在中国获得胶质母细胞瘤 II 期临床试验的批准。