Department of Applied Biotech, Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
Mini Rev Med Chem. 2021;21(3):273-287. doi: 10.2174/1389557520666201021143257.
Centipeda minima (the family Asteraceae) is an annual herbaceous plant native to the tropical regions, especially in eastern tropical Asia. C. minima is well-known in the list of medicinal plants with capacities in treatment of whooping cough, nasal allergy, malaria, and asthma. More than sixty reports on phytochemical and pharmacological aspects of this plant are now available, but a supportive review is insufficient.
The current review aims to make a compilation of almost all of the isolated compounds from the title plant, together with their pharmacological activities.
Centipeda minima is a meaningful keyword to search for previous references, while the reliable databases, such as Sci-Finder, Google Scholar, Pub Med, Science Direct, the Web of Science, Scopus, Bentham science, Taylor Francis, Springer, IOP Science were utilized at most.
More than one hundred secondary metabolites, classifying as terpenoids, flavonoids, mono-phenols, fatty acids, amides, and other types, were isolated from this plant. Among them, sesquiterpene lactones are dominant in either C. minima species or numerous plants of genus Centipeda. These phytochemical groups also possessed various biological results like anti-cancer, anti-bacteria, anti-allergy, anti-virus, anti-inflammation, and hepatoprotective activities. With many kinds of bioactive results such as anti-cancer and anti-inflammation, the use of C. minima plant extracts and isolated compounds for drug development seems to be a futuristic strategy.
最小堇菜（菊科）是一种一年生草本植物，原产于热带地区，尤其在东热带亚洲。最小堇菜是一种广为人知的药用植物，具有治疗百日咳、鼻过敏、疟疾和哮喘的功效。目前已有六十多份关于该植物的植物化学和药理学方面的报告，但缺乏支持性的综述。
本综述旨在对从该植物中分离得到的化合物及其药理学活性进行总结。
最小堇菜是一个有意义的关键词，用于搜索以前的参考文献，同时还利用了 Sci-Finder、Google Scholar、Pub Med、Science Direct、Web of Science、Scopus、Bentham science、Taylor Francis、Springer、IOP Science 等可靠数据库。
从该植物中分离出了 100 多种次生代谢产物，包括萜类、黄酮类、单酚类、脂肪酸、酰胺类和其他类型。其中，倍半萜内酯在最小堇菜属或该属的许多植物中都占优势。这些植物化学物质群具有多种生物活性，如抗癌、抗菌、抗过敏、抗病毒、抗炎和保肝活性。由于具有抗癌和抗炎等多种生物活性，因此利用最小堇菜植物提取物和分离得到的化合物进行药物开发似乎是一种具有前瞻性的策略。
