Liu Cheng, Zhao Zhining, Lv Hongqian, Yu Jia, Zhang Peng
Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Colloids Surf B Biointerfaces. 2022 Nov;219:112818. doi: 10.1016/j.colsurfb.2022.112818. Epub 2022 Sep 1.
As an emerging novel drug delivery system, microneedles (MNs) have a wide range of applications in the medical field. They can overcome the physiological barriers of the skin, penetrate the outermost skin of the human body, and form hundreds of reversible microchannels to enhance the penetration of drugs and deliver drugs to the diseased sites. So they have great applications in the diagnosis and treatment of melanoma. Melanoma is a kind of malignant tumor, the survival rate of patients with metastases is extremely low. The traditional methods of surgery and drug treatment for melanoma are often accompanied by large adverse reactions in the whole body, and the drug concentration is low. The use of MNs for transdermal administration can increase the drug concentration, reduce adverse reactions in the treatment process, and have good therapeutic effect on melanoma. This paper introduced various types of MNs and their preparation methods, summarized the diagnosis and various treatment options for melanoma with MNs, focused on the treatment of melanoma with dissolved MNs, and made prospect of MNs-mediated transdermal drug delivery in the treatment of melanoma.
作为一种新兴的新型药物递送系统，微针在医学领域有着广泛的应用。它们能够克服皮肤的生理屏障，穿透人体最外层皮肤，并形成数百个可逆的微通道，以增强药物的渗透并将药物递送至患病部位。因此，它们在黑色素瘤的诊断和治疗中具有巨大的应用价值。黑色素瘤是一种恶性肿瘤，发生转移的患者生存率极低。传统的黑色素瘤手术和药物治疗方法常常伴随着全身性的较大不良反应，且药物浓度较低。使用微针进行透皮给药可以提高药物浓度，减少治疗过程中的不良反应，并对黑色素瘤具有良好的治疗效果。本文介绍了各种类型的微针及其制备方法，总结了使用微针诊断和治疗黑色素瘤的各种选择，重点阐述了溶解型微针对黑色素瘤的治疗，并对微针介导的透皮给药在黑色素瘤治疗中的应用进行了展望。
