Wang Rui, Jiang Guohua, Aharodnikau Uladzislau E, Yunusov Khaydar, Sun Yanfang, Liu Tianqi, Solomevich Sergey O
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
Macromol Rapid Commun. 2022 Apr;43(8):e2200037. doi: 10.1002/marc.202200037. Epub 2022 Mar 23.
In recent years, transdermal drug delivery based on microneedles (MNs) technology has received extensive attention, which offers a safer and painless alternative to hypodermic needle injections. They can pierce the stratum corneum and deliver drugs to the epidermis and dermis-structures of skin, showing prominent properties such as minimally invasiveness, bypassing first-pass metabolism, and can be self-administered. A range of materials has been used to fabricate MNs, such as silicon, metal, glass, and polymers. Among them, polymer MNs have gained increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. MN products have recently become available on the market, and some of them are under evaluation for efficacy and safety. This paper focuses on the current state of polymer MNs in drug transdermal delivery. The materials and methods for the fabrication of polymer MNs and their drug administration are described. The recent progress of polymer MNs for treatment of cancer, vaccine delivery, blood glucose regulation, androgenetic alopecia, obesity, tissue healing, myocardial infarction, and gout are reviewed. The challenges of MNs technology are summarized and the future development trend of MNs is also prospected.
近年来，基于微针（MNs）技术的经皮给药受到了广泛关注，它为皮下注射提供了一种更安全、无痛的替代方法。微针能够穿透角质层并将药物递送至皮肤的表皮和真皮结构，具有微创性、绕过首过代谢以及可自我给药等显著特性。一系列材料被用于制造微针，如硅、金属、玻璃和聚合物。其中，聚合物微针作为一种有前景的给药方法，越来越受到制药和化妆品公司的关注。微针产品最近已投放市场，其中一些正在进行疗效和安全性评估。本文重点介绍了聚合物微针在药物经皮递送方面的现状。描述了聚合物微针的制备材料和方法及其给药方式。综述了聚合物微针在癌症治疗、疫苗递送、血糖调节、雄激素性脱发、肥胖症、组织愈合、心肌梗死和痛风治疗等方面的最新进展。总结了微针技术面临的挑战，并展望了微针的未来发展趋势。
