Universidad de Alcalá, Department of Biological Systems/Physiology, 28871 Alcalá de Henares, Spain.
Environ Pollut. 2022 Nov 15;313:120106. doi: 10.1016/j.envpol.2022.120106. Epub 2022 Sep 6.
Plastic waste pollution is one of the leading environmental problems of modern society. Its use, disposal, and recycling lead to the release of xenobiotic compounds such as bisphenol A (BPA), a known endocrine disruptor related to numerous pathologies. Due to the new restrictions on its use, it is gradually being replaced by derived molecules, such as bisphenol F or S (BPF or BPS), whose health risks have not yet been adequately studied. In the present work, significant relationships between the new BPA substitute molecules and renal and cardiovascular diseases have been detected by performing binomial and multinomial logistic regressions in one of the world's largest cohorts of urinary phenols. The results have shown a significant relationship between urinary BPF and renal function or heart disease (specifically congestive heart failure). Urinary BPS has shown a positive relationship with the risk of hypertension and a negative relationship with kidney disease. Consequently, applying new substitute molecules could imply potential health risks equivalent to BPA.
塑料废物污染是现代社会主要的环境问题之一。其使用、处置和回收会导致释放出诸如双酚 A（BPA）等外源性化合物，BPA 是一种已知的内分泌干扰物，与许多病理学有关。由于对其使用的新限制，它正逐渐被衍生分子如双酚 F 或 S（BPF 或 BPS）取代，而其健康风险尚未得到充分研究。在目前的工作中，通过在世界上最大的尿液酚类物质队列之一中进行二项式和多项逻辑回归，发现了新的 BPA 替代分子与肾脏和心血管疾病之间的显著关系。结果表明，尿 BPF 与肾功能或心脏病（特别是充血性心力衰竭）之间存在显著关系。尿 BPS 与高血压风险呈正相关，与肾脏疾病呈负相关。因此，应用新的替代分子可能意味着相当于 BPA 的潜在健康风险。
