脐带血白细胞端粒长度与婴儿期至青春期肥胖生长的关联。
Associations of cord blood leukocyte telomere length with adiposity growth from infancy to adolescence.
机构信息
Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
出版信息
Pediatr Obes. 2023 Jan;18(1):e12977. doi: 10.1111/ijpo.12977. Epub 2022 Sep 9.
OBJECTIVE
Leukocyte telomere length (LTL) may be a biomarker for chronic disease susceptibility, but no work has tested this hypothesis directly. Our study investigated associations of LTL at birth with markers of adiposity growth that are linked with cardiometabolic health later in life.
METHODS
Participants were 375 children in Project Viva (48% female, 71% White). Body mass index (BMI) trajectories from birth to 18 years were tracked using repeated measures of BMI collected in physical examinations and via medical records, then used to predict age (months) and magnitude (kg/m ) of BMI peak and rebound. LTL was measured from cord blood via duplex quantitative PCR. A binary variable indicating LTL shorter than the reference population average was the primary exposure.
RESULTS
LTL was unrelated to BMI at peak or rebound, but associations were apparent with the timing of BMI growth milestones. Short LTL was related to a later age of peak for females (β = 0.99, 95% CI = 0.16, 1.82; p = 0.015) and an earlier age of rebound for both males and females (β = -5.26, 95% CI = -9.44, -1.08).
CONCLUSION
LTL at birth may be an early biomarker of altered adiposity growth. Newborn telomere biology may shed new insight into the developmental origins of health and disease.
目的
白细胞端粒长度（LTL）可能是慢性病易感性的生物标志物，但尚无研究直接检验这一假说。本研究调查了出生时 LTL 与与成年后心血管代谢健康相关的肥胖生长标志物之间的关联。
方法
研究对象为 375 名参加 Viva 研究的儿童（48%为女性，71%为白人）。从出生到 18 岁的体重指数（BMI）轨迹通过体格检查和医疗记录中重复测量 BMI 进行追踪，然后用于预测 BMI 峰值和反弹的年龄（月）和幅度（kg/m）。LTL 通过双链定量 PCR 从脐带血中测量。LTL 短于参考人群平均值的二分变量是主要暴露因素。
结果
LTL 与 BMI 峰值或反弹无关，但与 BMI 生长里程碑的时间有关。LTL 短与女性 BMI 峰值年龄较晚有关（β=0.99，95%CI=0.16，1.82；p=0.015），与男性和女性 BMI 反弹年龄较早有关（β=-5.26，95%CI=-9.44，-1.08）。
结论
出生时的 LTL 可能是肥胖生长改变的早期生物标志物。新生儿端粒生物学可能为健康与疾病的发育起源提供新的见解。
Zotero 插件