Kumar R V, Gokhale S V, Ambaye R Y, Shetty P A
Chemotherapy. 1987;33(4):234-9. doi: 10.1159/000238500.
Any significant change in the pharmacokinetics of an anticancer drug would have a bearing on its therapeutic efficacy and toxicity. Nutritional deficiencies have been shown to affect the pharmacokinetics of a drug. Since malnutrition and undernutrition are widely prevalent in India, the effect of initial nutritional status on the overall kinetics of methotrexate (MTX) administered to cancer patients appeared to be of practical importance. A study of 6 Indian children with malignancies was made to examine the pharmacokinetics of low dose MTX and its relationship to the nutritional status. The results indicate that the relative weight correlates well with the anthropometric parameters, nutritional parameters and dietary intake and may be used as a marker of nutritional status.
抗癌药物药代动力学的任何显著变化都会对其治疗效果和毒性产生影响。已证明营养缺乏会影响药物的药代动力学。由于营养不良和营养不足在印度广泛存在，初始营养状况对癌症患者使用甲氨蝶呤（MTX）的整体动力学的影响似乎具有实际重要性。对6名患有恶性肿瘤的印度儿童进行了一项研究，以检查低剂量MTX的药代动力学及其与营养状况的关系。结果表明，相对体重与人体测量参数、营养参数和饮食摄入量密切相关，可作为营养状况的指标。
