Dan M, Golomb J, Gorea A, Lindner A, Berger S A
Chemotherapy. 1987;33(4):240-2. doi: 10.1159/000238501.
Concomitant concentrations of norfloxacin in serum, urine and prostatic tissue were determined in 12 patients following a single oral dose of 400 mg. Tissue levels ranged from 0.3 to 1.73 mg/kg, and therapeutic concentrations were demonstrable for as long as 8 h following dosage. The mean ratio of tissue to serum concentration was 1.01 +/- (SE) 0.13.
对12名患者单次口服400毫克诺氟沙星后，测定了血清、尿液和前列腺组织中的诺氟沙星伴随浓度。组织浓度范围为0.3至1.73毫克/千克，给药后长达8小时可检测到治疗浓度。组织与血清浓度的平均比值为1.01±（标准误）0.13。
