Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:4860-4863. doi: 10.1109/EMBC48229.2022.9871058.
IMDs are typically considered for chronic-use applications and a limited set of implant locations. Resorbable IMDs seek to combine advances in flexible electronics with functional soft materials to enable new applications, including acute care, aiming at temporary interfacing with soft tissues. Poly(oc-tamethylene maleate (anhydride) citrate) (POMaC) is an elasto-mer with demonstrated high biocompatibility and bioresorbability, as well as tunable stiffness and surface properties. Despite its promises, POMaC has not yet been applied in engineering flexible electronics. Herein, a POMaC-based circuit board is demonstrated and characterized. The monomer composition and thermal degradation properties of the pre-polymer was characterized. POMaC-based circuit boards were constructed using traditional microfabrication methods, including spin coating and metallization. POMaC pre-polymer and films were thermally stable to 300°C, exhibit controlled degradation in simulated physiological conditions, and are cytocompatible. Deposited traces were stable during fabrication and processing, and an LED circuit was designed and fabricated using surface mount devices on a POMaC-circuit board. The results indicate the feasibility of POMaC-based circuit boards for use in resorbable IMDs. Future work will investigate more complex circuits, fully encapsulated devices, and mechanical characterization.
可吸收式医疗器材通常用于慢性应用和有限的植入位置。可吸收式医疗器材旨在将柔性电子技术的进步与功能软材料相结合，以实现新的应用，包括急性护理，旨在与软组织临时接口。聚（辛烷二酸酐柠檬酸酯）（POMaC）是一种弹性体，具有高生物相容性和可生物降解性，以及可调的硬度和表面性能。尽管有其承诺，但 POMaC 尚未应用于工程柔性电子产品。本文展示并表征了基于 POMaC 的电路板。对预聚物的单体组成和热降解性能进行了表征。使用传统的微制造方法，包括旋涂和金属化，构建了基于 POMaC 的电路板。POMaC 预聚物和薄膜在 300°C 下稳定，在模拟生理条件下具有可控的降解性，并且细胞相容性好。沉积痕迹在制造和加工过程中稳定，并且使用表面贴装器件在 POMaC 电路板上设计和制造了 LED 电路。结果表明 POMaC 基电路板在可吸收式医疗器材中的应用具有可行性。未来的工作将研究更复杂的电路、完全封装的设备和机械特性。
