Montgomery Miles, Davenport Huyer Locke, Bannerman Dawn, Mohammadi Mohammad Hossein, Conant Genevieve, Radisic Milica
Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada.
ACS Biomater Sci Eng. 2018 Nov 12;4(11):3691-3703. doi: 10.1021/acsbiomaterials.7b01017. Epub 2018 Mar 15.
Using the methods described herein, we have demonstrated how scaffolds can be designed for a number of applications including tissue engineering, biomedical devices and injectable tissues. Details on the methods of polymerization and physical and chemical characterization of poly(octamethylene maleate (anhydride) citrate (POMaC) are described. Two POMaC polymer recipes with different monomer ratios of maleic anhydride and citric acid were synthesized and compared. Mechanical testing was performed on scaffolds of two distinct anisotropic designs to show how scaffold design influences the apparent elasticity in the long and short axis. POMaC scaffolds of various patterns and geometries were fabricated to demonstrate: (1) scaffold function can be determined by scaffold design (e.g., inherent shape-memory or self-assembling tubular structures), and (2) the soft lithography approach to fabricating biodegradable elastomers described here can be used to suit a number of different potential applications.
使用本文所述的方法，我们已经展示了如何为包括组织工程、生物医学设备和可注射组织在内的多种应用设计支架。文中描述了聚（马来酸（酐）柠檬酸辛二醇酯（POMaC））的聚合方法以及物理和化学表征的细节。合成并比较了两种具有不同马来酸酐和柠檬酸单体比例的POMaC聚合物配方。对两种不同各向异性设计的支架进行了力学测试，以展示支架设计如何影响长轴和短轴上的表观弹性。制备了各种图案和几何形状的POMaC支架，以证明：（1）支架功能可由支架设计决定（例如，固有形状记忆或自组装管状结构），以及（2）本文所述的用于制造可生物降解弹性体的软光刻方法可用于适应多种不同的潜在应用。
