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硬膜外类固醇注射后出现非典型病原体引起的硬膜外脓肿形成:一例报告。

Epidural abscess formation with an atypical pathogen following epidural steroid injection: A case report.

机构信息

Department of Rehabilitation Medicine, Hanyang University College of Medicine, Seoul, Korea.

出版信息

Medicine (Baltimore). 2022 Sep 9;101(36):e30495. doi: 10.1097/MD.0000000000030495.

DOI:10.1097/MD.0000000000030495
PMID:36086689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10980402/
Abstract

RATIONALE

Subcutaneous and epidural abscesses following epidural injection are a serious but rare complication. Epidural abscesses are typically caused by Staphylococcus aureus bacterial infection. In this case presented here, the causative bacterium was Enterococcus faecalis.

PATIENT CONCERNS

A 67-year-old woman having chronic lower back and right leg pain with past history of 20 years of rheumatoid arthritis, diabetes mellitus, and osteoporosis (T-score: -2.7) visited the outpatient pain clinic. Magnetic resonance imaging (MRI) revealed L4-5 right central disc extrusion with inferior migration. We performed a continuous epidural block for 7 days without complications. After 10 days, she presented with worsened low back pain, erythematous skin change on the lower back, chilling, and elevated serum acute phase reactants.

DIAGNOSIS

The diagnosis was subsequently confirmed by MRI suggesting subcutaneous and epidural abscess. Blood and pus cultures showed the growth of E. faecalis.

INTERVENTIONS

Pigtail catheter drainage was performed and intravenous antibiotics (ampicillin-sulbactam) targeting E. faecalis were applied for 3 weeks. Oral antibiotics (amoxicillin/potassium clavulanate) were applied for 6 weeks after discharge.

OUTCOMES

At the 2-month follow-up, improvement in both the clinical condition and serum acute phase reactants levels were noted.

LESSONS

Epidural injection can lead to a subcutaneous abscess that is further extended into the epidural space. One of the key factors is the presence of comorbid conditions, including diabetes mellitus and prolonged steroid usage due to rheumatoid arthritis.

摘要

背景

硬膜外注射后发生皮下和硬膜外脓肿是一种严重但罕见的并发症。硬膜外脓肿通常由金黄色葡萄球菌细菌感染引起。在本例中,致病菌为粪肠球菌。

病例介绍

一位 67 岁女性,患有慢性下腰痛和右下肢痛,有 20 年类风湿关节炎、糖尿病和骨质疏松症病史(T 评分:-2.7),曾在疼痛门诊就诊。磁共振成像(MRI)显示 L4-5 右侧中央椎间盘突出伴向下移位。我们进行了 7 天的连续硬膜外阻滞,无并发症。10 天后,她出现下腰痛加重、下背部红斑、寒战和血清急性期反应物升高。

诊断

随后 MRI 诊断为皮下和硬膜外脓肿。血液和脓液培养显示粪肠球菌生长。

干预措施

进行了猪尾导管引流,并应用针对粪肠球菌的静脉注射抗生素(氨苄西林-舒巴坦)治疗 3 周。出院后口服抗生素(阿莫西林/克拉维酸钾)治疗 6 周。

结果

在 2 个月的随访中,临床状况和血清急性期反应物水平均有所改善。

教训

硬膜外注射可导致皮下脓肿进一步扩展至硬膜外间隙。其中一个关键因素是存在合并症,包括糖尿病和由于类风湿关节炎而长期使用类固醇。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02a2/10980402/918a05eea766/medi-101-e30495-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02a2/10980402/5149b9d1332f/medi-101-e30495-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02a2/10980402/c45bc1ba3cf9/medi-101-e30495-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02a2/10980402/d96df8fe3366/medi-101-e30495-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02a2/10980402/918a05eea766/medi-101-e30495-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02a2/10980402/5149b9d1332f/medi-101-e30495-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02a2/10980402/c45bc1ba3cf9/medi-101-e30495-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02a2/10980402/d96df8fe3366/medi-101-e30495-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02a2/10980402/918a05eea766/medi-101-e30495-g004.jpg

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