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采用定量蛋白质组学方法鉴定接受联合脊髓-硬膜外麻醉行经尿道前列腺切除术患者脑脊液中围手术期神经认知功能障碍的生物标志物。

Identification of perioperative neurocognitive dysfunction biomarkers in cerebrospinal fluid with quantitative proteomic approach in patients undergoing transurethral resection of prostate with combined spinal and epidural analgesia.

机构信息

Department of Anesthesiology, Hospital (t.c.m) affiliated to southwest medical university, Luzhou, China.

Department of Urology, Hejiang Hospital of Traditional Chinese Medicine, Luzhou, China.

出版信息

Medicine (Baltimore). 2022 Sep 9;101(36):e30448. doi: 10.1097/MD.0000000000030448.

DOI:10.1097/MD.0000000000030448
PMID:36086739
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10980413/
Abstract

BACKGROUND

This study aimed to identify predictive biomarkers of perioperative neurocognitive dysfunction (PND) in cerebrospinal fluid of elderly male patients undergoing elective transurethral resection of prostate, using an isobaric tags for relative and absolute quantitative-based quantitative proteomic approach.

METHODS

Patients were evaluated with Mini Mental State Examination at -1 and+3 days of operation. Presence of PND was determined with Z-score method. Patients characteristics and quantitative cerebrospinal fluid proteomes detected with isobaric tags for relative and absolute quantitative-were compared between PND and non-PND patients. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis were performed to identify pathways potentially involved in PND.

RESULT

A total of 229 patients were included in the study and 32 were diagnosed with PND (incidence 14.4%). The age, incidence of hypertension, and diabetes of PND patients were significantly higher than non-PND patients (P < .05). There were 85 differentially expressed proteins identified, among which High Mobility Group Box 1, prostaglandin D synthase, and matrix metalloproteinase inhibitor were considered to be promising candidates as they might play important roles in pathophysiology of PND.

CONCLUSION

Proteomic approach identified potential biomarkers for predicting the occurrence of PND. These findings need to be validated in further studies.

摘要

背景

本研究旨在采用基于等重标记相对和绝对定量的蛋白质组学定量方法，鉴定接受择期经尿道前列腺切除术的老年男性患者围手术期神经认知功能障碍（PND）的脑脊液预测性生物标志物。

方法

患者在术前-1 天和术后+3 天接受 Mini 精神状态检查。采用 Z 评分法确定 PND 的存在。比较 PND 和非 PND 患者之间患者特征和等重标记相对和绝对定量检测到的定量脑脊液蛋白质组。进行基因本体论和京都基因与基因组百科全书分析，以确定可能与 PND 相关的途径。

结果

共有 229 例患者纳入研究，32 例患者被诊断为 PND（发生率为 14.4%）。PND 患者的年龄、高血压发生率和糖尿病发生率明显高于非 PND 患者（P<.05）。共鉴定出 85 种差异表达蛋白，其中高迁移率族蛋白 1、前列腺素 D 合酶和基质金属蛋白酶抑制剂被认为是有前途的候选标志物，因为它们可能在 PND 的病理生理学中发挥重要作用。

结论

蛋白质组学方法鉴定了预测 PND 发生的潜在生物标志物。这些发现需要在进一步的研究中得到验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de74/10980413/c88c8399732a/medi-101-e30448-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de74/10980413/1a7596be07a9/medi-101-e30448-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de74/10980413/40d0734181b6/medi-101-e30448-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de74/10980413/c88c8399732a/medi-101-e30448-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de74/10980413/1a7596be07a9/medi-101-e30448-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de74/10980413/40d0734181b6/medi-101-e30448-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de74/10980413/ead47b2f7254/medi-101-e30448-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de74/10980413/a93f7f5f0513/medi-101-e30448-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de74/10980413/562c4297688c/medi-101-e30448-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de74/10980413/c88c8399732a/medi-101-e30448-g006.jpg

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