UCLA Department of History and Institute for Society and Genetics.
Ber Wiss. 2022 Sep;45(3):462-467. doi: 10.1002/bewi.202200025.
Just when molecular biology is arguably delivering on some of its long-promised medical applications-think mRNA vaccines, monoclonal antibody drugs, PCR testing, and gene therapies-the history of molecular biology has lost much of its shine. What not too long ago seemed like a burgeoning field of research with endless possibilities, is now often reduced to the "central dogma" that saw its apotheosis in the effort to sequence the human genome but has since unraveled. The essay will discuss several possible answers to this apparent paradox.
正当分子生物学可以说正在实现其一些长期承诺的医学应用时——想想 mRNA 疫苗、单克隆抗体药物、PCR 检测和基因疗法——分子生物学的历史已经失去了很多光彩。不久前，这个领域似乎还是一个充满无限可能的新兴研究领域，现在却常常被简化为“中心法则”，该法则在人类基因组测序的努力中达到了顶峰，但此后却解体了。本文将讨论对这一明显悖论的几种可能的解答。
