Evidensia Referral Hospitals, Arnhem, The Netherlands.
Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
J Vet Intern Med. 2022 Nov;36(6):1872-1881. doi: 10.1111/jvim.16532. Epub 2022 Sep 10.
Dystonia is a clinical sign and main feature of many movement disorders in humans as well as veterinary species. It is characterized by sustained or intermittent involuntary muscle contractions causing abnormal (often repetitive) movements, postures, or both. This review discusses the terminology and definition of dystonia, its phenomenology, and its pathophysiology, and provides considerations regarding the diagnosis and treatment of dystonia in dogs and cats. In addition, currently recognized or reported disorders in dogs and cats in which dystonia is a particular or main feature are discussed and comparisons are made between disorders featuring dystonia in humans and animals. We suggest that when describing the phenomenology of dogs and cats with dystonia, if possible the following should be included: activity being performed at onset (e.g., resting or running or exercise-induced), body distribution, duration, responsiveness (subjective), severity, temporal pattern (i.e., paroxysmal or persistent, severity at onset and at later stages), presence or absence of autonomic signs (e.g., salivation), presence or absence of preceding signs (e.g., restlessness), presence or absence of signs after dystonia subsides (e.g., sleepiness), coexistence of other movement disorders, any other neurological manifestations, and possible links to administered medications, intoxications or other associated factors. We also suggest that dystonia be classified based on its etiology as either structural genetic, suspected genetic, reactive, or unknown.
肌张力障碍是人类和兽医物种许多运动障碍的临床征象和主要特征。其特征为持续或间歇性不自主肌肉收缩引起异常(通常为重复性)运动、姿势或两者兼有。本文讨论了肌张力障碍的术语和定义、现象学及其病理生理学,并就犬和猫的肌张力障碍的诊断和治疗提供了相关注意事项。此外,本文还讨论了目前公认或报道的犬和猫中以肌张力障碍为特定或主要特征的疾病,并对以肌张力障碍为特征的人类和动物疾病进行了比较。我们建议,在描述伴有肌张力障碍的犬和猫的现象学时,如果可能,应包括以下内容:发病时的活动(例如,休息、跑步或运动诱发)、身体分布、持续时间、反应性(主观)、严重程度、时间模式(即阵发性或持续性、发病时和后期的严重程度)、是否存在自主神经征象(例如,流涎)、是否存在前驱征象(例如,不安)、肌张力障碍消退后是否存在征象(例如,嗜睡)、是否共存其他运动障碍、任何其他神经表现以及与使用的药物、中毒或其他相关因素的可能关联。我们还建议根据病因将肌张力障碍分为结构性遗传、疑似遗传、反应性或未知。