Department of Otorhinolaryngology-Head and Neck Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Department of Otorhinolaryngology-Head and Neck Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China;
Allergol Immunopathol (Madr). 2022 Sep 1;50(5):7-15. doi: 10.15586/aei.v50i5.615. eCollection 2022.
Allergic rhinitis (AR) is a common otolaryngologic disease with frequent episodes of sneezing, clear nasal discharge flow and nasal congestion. The mechanisms of AR are complex and considered generally caused by the immune tolerance deficiency. Regulatory B cells (Bregs) are immunosuppressive cells that can modulate immune responses by the secretion of IL-10, IL-35, and tumor growth factor-β (TGF-β) and via the interaction of membrane surface molecules. However, Bregs are numerically deficient and/or dysfunctional in airway allergic diseases such as AR and allergic asthma, and the related mechanisms remain unclear. In this review, we summarize the role of Bregs in AR pathogenesis and highlight the importance of Bregs in maintaining immune tolerance. It is believed that further research on Bregs will contribute to developing new treatments and finding specific biomarkers that could help to predict disease progression.
变应性鼻炎（AR）是一种常见的耳鼻喉科疾病，常伴有打喷嚏、流清涕和鼻塞。AR 的发病机制复杂，一般认为与免疫耐受缺陷有关。调节性 B 细胞（Bregs）是具有免疫抑制作用的细胞，通过分泌白细胞介素-10（IL-10）、白细胞介素-35（IL-35）和转化生长因子-β（TGF-β），以及通过膜表面分子的相互作用，调节免疫反应。然而，在变应性鼻炎和过敏性哮喘等气道过敏性疾病中，Bregs 数量减少和/或功能障碍，其相关机制尚不清楚。在这篇综述中，我们总结了 Bregs 在 AR 发病机制中的作用，并强调了 Bregs 在维持免疫耐受中的重要性。相信对 Bregs 的进一步研究将有助于开发新的治疗方法和寻找有助于预测疾病进展的特定生物标志物。
