调节性 B 细胞在癌症中的作用。
The roles of regulatory B cells in cancer.
机构信息
Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
出版信息
J Immunol Res. 2014;2014:215471. doi: 10.1155/2014/215471. Epub 2014 Jun 2.
Abstract
Regulatory B cells (Bregs), a newly described subset of B cells, have been proved to play a suppressive role in immune system. Bregs can inhibit other immune cells through cytokines secretion and antigen presentation, which give them the role in the pathogenesis of autoimmune diseases and cancers. There are no clear criteria to identify Bregs; different markers were used in the different experimental conditions. Massive researches had described the functions of immune cells such as regulatory T cells (Tregs), dendritic cells (DCs), and B cells in the autoimmune disorder diseases and cancers. More and more researches focused on the roles of Bregs and the cytokines such as Interleukin-10 (IL-10) and transforming growth factor beta (TGF- β ) secreted by Bregs. The aim of this review is to summarize the characteristics of Bregs and the roles of Bregs in cancer.
摘要
调节性 B 细胞（Bregs），一种新描述的 B 细胞亚群，已被证明在免疫系统中发挥抑制作用。Bregs 通过细胞因子分泌和抗原呈递抑制其他免疫细胞，使其在自身免疫性疾病和癌症的发病机制中发挥作用。目前尚无明确的标准来鉴定 Bregs；在不同的实验条件下使用了不同的标记物。大量研究描述了调节性 T 细胞（Tregs）、树突状细胞（DCs）和 B 细胞在自身免疫性疾病和癌症中的功能。越来越多的研究关注 Bregs 及其分泌的细胞因子（如白细胞介素 10（IL-10）和转化生长因子β（TGF-β））的作用。本文综述的目的是总结 Bregs 的特征及其在癌症中的作用。
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本文引用的文献
1
Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice.
PLoS One. 2014 Jan 17;9(1):e83575. doi: 10.1371/journal.pone.0083575. eCollection 2014.
2
Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation.
Cell Metab. 2013 Nov 5;18(5):759-766. doi: 10.1016/j.cmet.2013.09.017. Epub 2013 Oct 24.
3
Role of IL-10-producing regulatory B cells in control of cerebral malaria in Plasmodium berghei infected mice.
Eur J Immunol. 2013 Nov;43(11):2907-18. doi: 10.1002/eji.201343512. Epub 2013 Aug 27.
4
T follicular helper cells mediate expansion of regulatory B cells via IL-21 in Lupus-prone MRL/lpr mice.
PLoS One. 2013 Apr 24;8(4):e62855. doi: 10.1371/journal.pone.0062855. Print 2013.
5
IL-10-producing regulatory B cells (B10 cells) in autoimmune disease.
Arthritis Res Ther. 2013;15 Suppl 1(Suppl 1):S1. doi: 10.1186/ar3907. Epub 2013 Feb 11.
6
B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells.
J Allergy Clin Immunol. 2013 Jun;131(6):1674-82. doi: 10.1016/j.jaci.2013.01.044. Epub 2013 Mar 25.
7
CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation.
Sci Transl Med. 2013 Feb 20;5(173):173ra23. doi: 10.1126/scitranslmed.3005407.
8
Cancer-produced metabolites of 5-lipoxygenase induce tumor-evoked regulatory B cells via peroxisome proliferator-activated receptor α.
J Immunol. 2013 Mar 15;190(6):2575-84. doi: 10.4049/jimmunol.1201920. Epub 2013 Feb 13.
9
Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.
Cancer Res. 2013 Apr 15;73(8):2468-79. doi: 10.1158/0008-5472.CAN-12-3450. Epub 2013 Feb 5.
10
Anti-CD20 antibody promotes cancer escape via enrichment of tumor-evoked regulatory B cells expressing low levels of CD20 and CD137L.
Cancer Res. 2013 Apr 1;73(7):2127-38. doi: 10.1158/0008-5472.CAN-12-4184. Epub 2013 Jan 30.
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