Postgraduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Department of Neurosciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
Child Psychiatry Hum Dev. 2024 Apr;55(2):552-563. doi: 10.1007/s10578-022-01419-3. Epub 2022 Sep 10.
Genetic alterations related to oxytocin system seem to influence the neurobiology of attention-deficit hyperactivity disorder and anxiety problems leading to greater functional, social and emotional impairment. Here, we analyzed the association of OXTR rs2254298 and CD38 rs6449182 variants with attention/hyperactivity problems and anxiety problems in children. The study enrolled 292 children and adjusted regression model revealed OXTR rs2254298 AA genotype as a risk factor for attention deficit/hyperactivity problems (PR: 2.37; P = 0.006), attention problems (PR: 2.71; P = 0.003) and anxiety problems (PR: 1.92; P = 0.018). CD38 rs6449182 G allele showed as a risk factor for attention deficit/hyperactivity problems (PR: 1.56; P = 0.028). Moreover, in silico approach for regulatory roles found markers that influence chromatin accessibility and transcription capacity. Together, these data provide genetic information of oxytocin in developmental and behavioral disorders opening a range of opportunities for future studies that clarify their neurobiology in childhood.
与催产素系统相关的遗传改变似乎会影响注意缺陷多动障碍和焦虑问题的神经生物学，导致更大的功能、社会和情感障碍。在这里，我们分析了 OXTR rs2254298 和 CD38 rs6449182 变体与儿童注意/多动问题和焦虑问题的关联。该研究纳入了 292 名儿童，调整后的回归模型显示 OXTR rs2254298 AA 基因型是注意缺陷/多动问题（PR：2.37；P = 0.006）、注意问题（PR：2.71；P = 0.003）和焦虑问题（PR：1.92；P = 0.018）的危险因素。CD38 rs6449182 G 等位基因是注意缺陷/多动问题（PR：1.56；P = 0.028）的危险因素。此外，用于调控作用的计算方法发现了影响染色质可及性和转录能力的标记物。总之，这些数据为催产素在发育和行为障碍中的遗传信息提供了依据，为未来阐明其在儿童时期的神经生物学的研究开辟了一系列机会。
