帕金森病中α-突触核蛋白特异性 T 细胞的检测。
Detection of α-Synuclein-Specific T Cells in Parkinson's Disease.
机构信息
Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.
Division of Extramural Activities, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD, USA.
出版信息
Methods Mol Biol. 2022;2574:123-131. doi: 10.1007/978-1-0716-2712-9_5.
Parkinson's disease (PD) is a widely prevalent chronic neurodegenerative disease. The disease is characterized by loss of dopaminergic neurons with abnormal aggregation of α-synuclein (α-syn). The misfolded deposition of α-syn is known to mount robust adaptive immune response by activating T cells. Here, we show that peripheral mononuclear cells when stimulated with a α-syn-derived peptide pool activate α-syn-specific T cells that produce cytokines.
帕金森病（PD）是一种广泛流行的慢性神经退行性疾病。该疾病的特征是多巴胺能神经元丧失，α-突触核蛋白（α-syn）异常聚集。已知α-syn 的错误折叠沉积通过激活 T 细胞引发强烈的适应性免疫反应。在这里，我们表明，当用源自α-syn 的肽池刺激外周单核细胞时，会激活产生细胞因子的α-syn 特异性 T 细胞。
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