Department of Pharmaceutical Sciences, Zunyi Medical University, Zhuhai Campus, Zhuhai 519041, PR China.
College of Pharmacy, Zunyi Medical University, Zunyi 563000, PR China.
Phytomedicine. 2022 Nov;106:154419. doi: 10.1016/j.phymed.2022.154419. Epub 2022 Aug 27.
Irritable bowel syndrome (IBS) is a kind of functional bowel disease that is characterized by bellyache, abdominal distension, and diarrhea. Although not life-threatening, IBS has a long course and recurrent attacks and seriously affects the life quality of patients. Current drugs for treating IBS possess remarkable limitations, such as limited efficacy and severe adverse reactions. Therefore, developing novel medications to treat IBS is quite essential, and natural products may be a substantial source.
This is the first systematic review elaborating the recent advancement of natural products as potential drugs for the therapy of IBS.
A comprehensive retrieval of studies was carried out in scientific databases including PubMed, Web of Science, Elsevier, and CNKI. By using ("irritable bowel syndrome" OR "IBS") AND ("natural product" OR "natural compound" OR "phytochemical") as keywords, the eligible studies were screened, and the relevant information about therapeutic action and mechanism of natural products treating IBS was extracted.
Natural products against IBS consisted of four categories, namely, terpenoids, flavonoids, alkaloids, and phenols. Furthermore, the underlying mechanisms for natural products treating IBS were tightly associated with increased TJs and mucus protein expression, regulation of the brain-gut axis and gut microbiota structure, and inhibition of inflammatory response and intestinal mucosal damage.
Natural products could be extremely prospective candidate drugs used to treat IBS, and further preclinical and clinical researches are needed to guarantee their efficacy and safety.
肠易激综合征（IBS）是一种功能性肠病，其特征为腹痛、腹胀和腹泻。尽管不会危及生命，但 IBS 病程长且反复发作，严重影响患者的生活质量。目前治疗 IBS 的药物存在疗效有限和严重不良反应等显著局限性。因此，开发治疗 IBS 的新型药物非常必要，而天然产物可能是一个重要的来源。
这是第一篇系统综述，详细阐述了天然产物作为治疗 IBS 潜在药物的最新进展。
在包括 PubMed、Web of Science、Elsevier 和中国知网在内的科学数据库中进行了全面检索。使用“irritable bowel syndrome”或“IBS”和“natural product”或“natural compound”或“phytochemical”作为关键词，筛选合格的研究，并提取关于天然产物治疗 IBS 的治疗作用和机制的相关信息。
治疗 IBS 的天然产物包括萜类化合物、黄酮类化合物、生物碱和酚类化合物四大类。此外，天然产物治疗 IBS 的潜在机制与增加 TJ 和粘蛋白表达、调节脑-肠轴和肠道微生物结构以及抑制炎症反应和肠道黏膜损伤密切相关。
天然产物可能是治疗 IBS 的极有前景的候选药物，需要进一步的临床前和临床研究来保证其疗效和安全性。
