瑞香狼毒根中的结构多样的二萜类化合物
Structurally diverse diterpenoids from the roots of Euphorbia fischeriana Steud.
机构信息
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, PR China.
出版信息
Fitoterapia. 2022 Oct;162:105296. doi: 10.1016/j.fitote.2022.105296. Epub 2022 Sep 8.
Four new diterpenoids (1-4), and 18 known ones were isolated from the roots of Euphorbia fischeriana Steud (Euphorbiaceae). These diterpenoids shared six skeleton types, including ent-atisane, kaurane, 3,4-secokaurane, lathyrane, 4,5-secoatisane and ingenane diterpenoids. The structures of the new diterpenoids were characterized by a combination of spectroscopic techniques and X-ray crystallography. Moreover, biological evaluation revealed that compounds (16S*)-atisan-3β,16,17-triol (7), (16S*)-3β,16,17,18-tetrahydroxykaurane (12) and (16S*)-3α-hydroxykauran-16,17-acetonide (15) showed inhibitory activity against the interferon regulatory factors (IRFs) involved pathway.
从大飞扬Euphorbia fischeriana Steud（大戟科）的根部分离得到四个新的二萜（1-4）和 18 个已知的二萜。这些二萜共享六种骨架类型，包括 ent-atisane、kaurane、3,4-secokaurane、lathyrane、4,5-secoatisane 和 ingenane 二萜。新二萜的结构通过光谱技术和 X 射线晶体学的组合来表征。此外，生物评价表明，化合物（16S*）-atisan-3β,16,17-三醇（7）、（16S*）-3β,16,17,18-四羟基-kaurane（12）和（16S*）-3α-羟基-kauran-16,17-乙缩醛（15）对涉及干扰素调节因子（IRFs）的途径表现出抑制活性。
Zotero 插件