School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China.
J Ethnopharmacol. 2022 Nov 15;298:115574. doi: 10.1016/j.jep.2022.115574. Epub 2022 Aug 6.
Euphorbia is one of the major genera in angiosperms, which is widely distributed all over the world, including Asia, Africa and Central and South America. The roots or tubers of Euphorbia are famous for medicinal purposes, especially in China. Many of them, such as Euphorbia pekinensis Rupr, Euphorbia fischeriana Steud and Euphorbia Kansui S.L.Liou ex S.B.Ho. . are used as Chinese herbal medicines.
This paper reviews the diterpenoids isolated from the genus Euphorbia species and the pharmacological activities of these compounds to evaluate its traditional use and potential future development.
Information on the studies of the genus Euphorbia Linn was collected from scientific journals, books and reports via library and electronic data search (Scifinder, Web of Science, PubMed, Elsevier, Scopus, Google Scholar, Springer, Science Direct, Wiley, ACS, CNKI and Kew Plants of the Word Online). Meanwhile, it was also obtained from published works of material medica, folk records, ethnophmacological literatures, Ph.D. and Masters dissertations.
Known as the main constituents of the genus Euphorbia Linn, Diterpenoids possess many pharmacological properties such as anti-inflammation, antiviral activities and cytotoxicity. To date, various types of diterpenoids were identified from this genus, including isopimarane, rosane, abietane, ent-kaurane, ent-atisane. cembrane, casbane, lathyrane, myrsinane, jatropholane, tigliane, ingenane, jatrophane, paraliane, pepluane, and euphoractin.
This review describes 14 types of diterpenoid isolated from 45 Euphorbia species from 2012 to 2021, a total of 615 compounds. Among them, mainly include jatrophane (171), lathyrane (92), myrsinane (62), abietane (70), ent-atisane (36), ent-kaurane (7), tigliane (26) and ingenane (19). The possible biological pathways of these compounds were presumed. At the same time, more than 10 biological activities of these compounds were summarized, such as anti-inflammation, antiviral activities and cytotoxicity.
大戟属是被子植物中最大的属之一，广泛分布于世界各地，包括亚洲、非洲和中美洲及南美洲。大戟属植物的根或块茎以药用而闻名，尤其是在中国。其中许多种，如大戟（Euphorbia pekinensis Rupr）、佛氏大戟（Euphorbia fischeriana Steud）和甘遂（Euphorbia kansui S.L.Liou ex S.B.Ho.），都被用作中草药。
本文综述了大戟属植物中分离得到的二萜类化合物及其化合物的药理活性，以评估其传统用途和潜在的未来发展。
通过图书馆和电子数据检索（Scifinder、Web of Science、PubMed、Elsevier、Scopus、Google Scholar、Springer、Science Direct、Wiley、ACS、CNKI 和 Kew Plants of the Word Online）从科学期刊、书籍和报告中收集了大戟属植物的研究信息。同时，还从药用植物、民间记录、民族药理学文献、博士和硕士论文等已发表的著作中获得了信息。
作为大戟属植物的主要成分，二萜类化合物具有多种药理活性，如抗炎、抗病毒活性和细胞毒性。迄今为止，已从该属中鉴定出各种类型的二萜类化合物，包括异松烷、罗斯烷、贝壳杉烷、新乌头烷、金合欢烷、海松烷、贝壳杉烷、拉蒂烷、杨梅烷、吉妥烷、替加烷、 ingenane、jatrophane、 paraliane、pepluane 和 euphoractin。
本文综述了 2012 年至 2021 年间从 45 种大戟属植物中分离得到的 14 种二萜类化合物，共 615 种化合物。其中，主要包括 jatrophane（171）、lathyrane（92）、myrsinane（62）、abietane（70）、ent-atisane（36）、ent-kaurane（7）、tigliane（26）和 ingenane（19）。推测了这些化合物的可能生物学途径。同时，总结了这些化合物的 10 多种生物活性，如抗炎、抗病毒活性和细胞毒性。
