Wang Chun-Jie, Yan Qiu-Long, Ma Yu-Fang, Sun Cheng-Peng, Chen Chang-Ming, Tian Xiang-Ge, Han Xiu-Yan, Wang Chao, Deng Sa, Ma Xiao-Chi
College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University , Dalian 116044, People's Republic of China.
J Nat Prod. 2017 May 26;80(5):1248-1254. doi: 10.1021/acs.jnatprod.6b00786. Epub 2017 Apr 6.
An investigation on the bioactive chemical constituents of the roots of Euphorbia fischeriana has been conducted, with 21 diterpenoids obtained using various chromatographic techniques. On the basis of spectroscopic data analysis, the new compounds were elucidated as four ent-abietane-type diterpenoids (1-4) and four tigliane-type diterpenoids (13-16). Also obtained were eight known ent-abietane (5-12) and five known tigliane (17-21) diterpenoids. The potential antituberculosis effects of these diterpenoids were evaluated using a Mycobacterium smegmatis model. The most potent compound according to the in vitro bioassay used was 17-hydroxyjolkinolide B (12) (MIC 1.5 μg/mL).
对狼毒大戟根的生物活性化学成分进行了研究，通过各种色谱技术获得了21种二萜类化合物。基于光谱数据分析，新化合物被鉴定为四种对映-贝壳杉烷型二萜（1-4）和四种大戟烷型二萜（13-16）。还获得了八种已知的对映-贝壳杉烷（5-12）和五种已知的大戟烷（17-21）二萜类化合物。使用耻垢分枝杆菌模型评估了这些二萜类化合物的潜在抗结核作用。根据所使用的体外生物测定，最有效的化合物是17-羟基jolkinolide B（12）（MIC 1.5μg/mL）。
