Research Institute for Biomaterials, Tech Institute for Advanced Materials, College of Materials Science and Engineering, NJTech-BARTY Joint Research Center for Innovative Medical Technology, Suqian Advanced Materials Industry Technology Innovation Center, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Nanjing Tech University, Nanjing 211816, PR China.
Research Institute for Biomaterials, Tech Institute for Advanced Materials, College of Materials Science and Engineering, NJTech-BARTY Joint Research Center for Innovative Medical Technology, Suqian Advanced Materials Industry Technology Innovation Center, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Nanjing Tech University, Nanjing 211816, PR China.
Carbohydr Polym. 2022 Nov 15;296:119953. doi: 10.1016/j.carbpol.2022.119953. Epub 2022 Aug 4.
Hydrogel tissue adhesives that currently available are often fabricated by mixing two or more polymeric components. Single-component hydrogels afford injectability, strong and reversible adhesion remain a formidable challenge. This research describes the creation of the first single-component hyaluronic acid hydrogel adhesive-based on phenylboronic acid-diol ester linkages. Phenylboronic acid can not only serve as a cross-linker to form hydrogel, but also act as an adhesion site for glycosyl compounds found in biological cell membranes. The rheological and compressive tests for the hydrogel show that it has excellent self-healing properties, good injectability and strong compressive strength. Adhesion tests demonstrated that the hydrogel has significantly greater adhesion strength than commercial fibrin glue. These findings suggest that the rational design of hydrogel precursors facilitates the formation of single-component networks and multiple functionalities. In vivo studies further proved the hydrogel was an ideal bio-adhesive with biocompatibility, absorbed wound exudate and hemostasis, and accelerated wound closure.
目前市售的水凝胶组织粘合剂通常是通过混合两种或更多种聚合物成分来制备的。单组分水凝胶具有可注射性，但高强度和可重复的粘附仍然是一个巨大的挑战。本研究描述了基于苯硼酸-二醇酯键的第一种单组分透明质酸水凝胶粘合剂的制备。苯硼酸不仅可以作为交联剂形成水凝胶，还可以作为生物细胞膜中糖基化合物的粘附位点。水凝胶的流变和压缩测试表明，它具有优异的自修复性能、良好的可注射性和较强的压缩强度。粘附测试表明，该水凝胶的粘附强度明显大于商业纤维蛋白胶。这些发现表明，水凝胶前体的合理设计有利于形成单组分网络和多种功能。体内研究进一步证明，该水凝胶是一种具有生物相容性、吸收伤口渗出物和止血、加速伤口闭合的理想生物粘合剂。
