Azaïs V, Rachman F, Gros S, Pascal G, Amédée-Manesme O
Drug Nutr Interact. 1987;5(2):81-8.
Thirty-four Wistar rats were fed a marginal or normal vitamin A diet and received daily for 14 days an intragastric intubation of oil supplemented with 0, 20, or 60 mg X kg-1 of cyclosporine A. The hepatic content and concentration of vitamin A were significantly decreased by cyclosporine treatment, whereas no modification occurred in kidney or serum vitamin A levels. No induction of hepatic cytochrome P-450 was observed in treated animals. These results suggest that cyclosporine interferes with vitamin A stores; thus, vitamin A supplementation may be useful in patients receiving cyclosporine therapy. Drug-metabolizing enzymes, which are cytochrome P-450 dependent, did not seem to be involved in the hepatic vitamin A decrease observed.
将34只Wistar大鼠分为两组，分别给予边缘性或正常维生素A饮食，并连续14天每天经胃管给予补充了0、20或60 mg/kg环孢素A的油剂。环孢素治疗显著降低了肝脏中维生素A的含量和浓度，而肾脏或血清中维生素A水平未发生改变。在接受治疗的动物中未观察到肝脏细胞色素P-450的诱导。这些结果表明，环孢素会干扰维生素A的储存；因此，补充维生素A可能对接受环孢素治疗的患者有用。细胞色素P-450依赖性的药物代谢酶似乎与观察到的肝脏维生素A减少无关。
