Gilligan Gerardo, Piemonte Eduardo, Lazos Jerónimo, Simancas María Celeste, Panico René, Warnakulasuriya Saman
Oral Medicine Department, Facultad de Odontología, Universidad Nacional de Córdoba, Haya de la Torre SN, 5000, Córdoba, Argentina.
Pathology Service, Hospital Italiano de Córdoba, Córdoba, Argentina.
Clin Oral Investig. 2023 Jan;27(1):193-201. doi: 10.1007/s00784-022-04710-8. Epub 2022 Sep 10.
A proportion of oral squamous cell carcinoma (OSCC) is preceded by oral potentially malignant disorders (OPMD), and the rest might not be associated with any well-established OPMD. Chronic traumatic ulcer (CTU) has been suggested as a lesion with potential for malignant transformation, but the evidence is inconclusive.
The aim of this study was to describe clinicopathological features of non-healing CTU (NHCTU) that later developed to OSCC.
A retrospective cohort study was performed of patients attending the Facultad de Odontología Universidad Nacional de Córdoba (2013-2019). The study included patients with a provisional diagnosis of CTU. CTUs without complete healing after removal of traumatic factors-non healing CTU (NHCTU)-were investigated by biopsy. A detailed description of cases where a malignancy was diagnosed is presented.
A total of 107 CTU were included. Of these, 32 CTUs were considered NHCTU and two cases showed histological features of OSCC in the background of NHCTU. In both cases, lesions were found on the lateral tongue. Both were non smoking, non alcohol drinking individuals. Absence of any well-known OPMD was also registered.
The possibility of malignant transformation in a subset of tongue NHCTU should not be underestimated.
In a subgroup of patients, NHCTU could be considered an OPMD. Although the potential malignant transformation rate is low, these conditions should be always followed up.
一部分口腔鳞状细胞癌（OSCC）之前存在口腔潜在恶性疾病（OPMD），而其余部分可能与任何已明确的OPMD无关。慢性创伤性溃疡（CTU）被认为是一种具有恶性转化潜能的病变，但证据尚无定论。
本研究的目的是描述后来发展为OSCC的不愈合CTU（NHCTU）的临床病理特征。
对科尔多瓦国立大学牙科学院就诊的患者（2013 - 2019年）进行回顾性队列研究。该研究纳入了初步诊断为CTU的患者。对去除创伤因素后未完全愈合的CTU - 不愈合CTU（NHCTU）进行活检研究。对诊断为恶性肿瘤的病例进行详细描述。
共纳入107例CTU。其中，32例CTU被认为是NHCTU，2例在NHCTU背景下显示出OSCC的组织学特征。在这两个病例中，病变均位于舌侧。两人均不吸烟、不饮酒。也未发现任何已知的OPMD。
不应低估一部分舌部NHCTU发生恶性转化的可能性。
在一部分患者中，NHCTU可被视为一种OPMD。尽管潜在的恶性转化率较低，但这些情况应始终进行随访。
