Oral Medicine Department, Facultad de Odontología Universidad Nacional de Córdoba Haya de la Torre SN. Ciudad Universitaria, Córdoba, Argentina
Med Oral Patol Oral Cir Bucal. 2020 Sep 1;25(5):e706-e713. doi: 10.4317/medoral.23729.
Chronic wounds were previously related to cancer. Chronic Traumatic Ulcers (CTU) are lesions caused by chronic mechanical irritation (CMI) frequently diagnosed in Oral Medicine. Although these conditions may reflect a benign nature, some authors have proposed its relationship with malignant transformation. Currently, there are scarce investigations that evaluate biomarkers within CTU. The aim of this study was to evaluate cell differentiation and proliferation biomarkers patterns of CTU and OSCC through recognized markers such as cytokeratin 19 and Ki67 and correlate it with clinical features of both groups of patients.
A Cross-sectional study of adult patients (n=79), both sexes, attended at Oral Medicine Department, Facultad de Odontología, Universidad Nacional de Córdoba. The patients were classified into two groups: CTU (n=41), and OSCC (n=38). A subset of specimens were immunolabeled with Ki67 and Ck19.
The population consisted of 51.9% male and 48.1% female, with an average of 57.0 ± 13.9. years (OSCC group) and 60.9 ± 14.9 years (CTU group). OSCC group presented higher scores for both biomarkers (Ki67 and Ck19), but only there were differences statistically significant for Ki67 (p=0.032). 25% of non-healing CTU were positive with medium scores of Ck19 and showed an immunohistochemical profile similar to OSCC. The lateral tongue was the most frequent site in both groups.
The altered immunohistochemical pattern found in many specimens of CTU was also observed in OSCC. The tongue border presents physiological conditions that could offer a suitable environment for the development of neoplastic events associated with CMI. Further studies are needed to understand the underlying mechanisms that could link oral non-healing ulcers with early malignant changes.
慢性伤口以前与癌症有关。慢性创伤性溃疡（CTU）是由慢性机械刺激（CMI）引起的病变，常被诊断为口腔医学中的病变。尽管这些情况可能反映了良性性质，但一些作者提出了其与恶性转化的关系。目前，很少有研究评估 CTU 中的生物标志物。本研究旨在通过公认的标志物（如细胞角蛋白 19 和 Ki67）评估 CTU 和 OSCC 的细胞分化和增殖生物标志物模式，并将其与两组患者的临床特征相关联。
对在科尔多瓦国立大学牙科学院口腔医学系就诊的成年患者（n=79）进行了一项横断面研究，包括男女两性。患者被分为两组：CTU（n=41）和 OSCC（n=38）。一组标本用 Ki67 和 Ck19 进行免疫标记。
该人群中男性占 51.9%，女性占 48.1%，平均年龄为 57.0±13.9 岁（OSCC 组）和 60.9±14.9 岁（CTU 组）。OSCC 组两种生物标志物（Ki67 和 Ck19）的评分均较高，但只有 Ki67 的评分差异具有统计学意义（p=0.032）。25%的非愈合 CTU 对 Ck19 的中等评分呈阳性，并且表现出与 OSCC 相似的免疫组织化学特征。在两组中，舌侧缘是最常见的部位。
在许多 CTU 标本中发现的改变的免疫组织化学模式也在 OSCC 中观察到。舌缘具有可以为与 CMI 相关的肿瘤性事件的发展提供合适环境的生理条件。需要进一步研究来了解可能将口腔非愈合性溃疡与早期恶性变化联系起来的潜在机制。
