Voelker W, Schuler U, Ehninger G, Jacksch R, Mauser M, Steidle B, Karsch K R
Dtsch Med Wochenschr. 1987 Jul 31;112(31-32):1216-9. doi: 10.1055/s-2008-1068225.
An 18-year-old male patient with Hodgkin's disease, having undergone radiotherapy to the mediastinum two-and-a-half years previously, developed symptoms of an acute myocardial infarction within three hours of a vincristine injection (the first course of vincristine chemotherapy had been finished eight days previously). Invasive investigation after three weeks revealed single-vessel occlusion of the anterior interventricular branch with an anterior-wall aneurysm. The most likely cause of the coronary heart disease in this patient is changes in the anterior interventricular branch resulting from the mediastinal radiotherapy. The infarct itself occurred in close temporal relationship to the vincristine injection, which in several case reports has been implicated in the triggering of coronary spasms.
一名18岁男性霍奇金病患者，两年半前接受过纵隔放疗，在注射长春新碱（长春新碱化疗的第一个疗程已于八天前结束）三小时内出现急性心肌梗死症状。三周后的侵入性检查显示前室间支单支血管闭塞并伴有前壁动脉瘤。该患者冠心病最可能的病因是纵隔放疗导致的前室间支改变。梗死本身与长春新碱注射在时间上密切相关，在一些病例报告中，长春新碱被认为可引发冠状动脉痉挛。
