Student Research Committee, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, P.O. Box: 76175-493, 76169-11319, Kerman, Iran.
Chemosphere. 2022 Dec;308(Pt 2):136336. doi: 10.1016/j.chemosphere.2022.136336. Epub 2022 Sep 8.
The present attempt developed a simple sensing system based on the modification of screen-printed carbon electrode (SPCE) with MoSe/reduced graphene oxide (rGO) nanocomposite (MoSe-rGO/SPCE) to voltammetrically co-detect amitriptyline and carbamazepine. Different techniques such as field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) were employed to characterize MoSe-rGO nanocomposite morphology and structure. Moreover, chronoamperometry, differential pulse voltammetry (DPV) and linear sweep voltammetry (LSV) were utilized to explore the electrochemical oxidation of amitriptyline. Data revealed a great current sensitivity for the MoSe-rGO/SPCE towards amitriptyline. The peak currents of amitriptyline oxidation on the MoSe-rGO/SPCE had linear dynamic range (0.02-380.0 μM) and a narrow limit of detection (0.007 μM). The MoSe-rGO/SPCE was successful in sensing carbamazepine and amitriptyline in real specimens, with appreciable recovery rates.
本研究尝试开发了一种基于丝网印刷碳电极（SPCE）修饰的简单传感系统，该系统采用 MoSe/reduced graphene oxide（rGO）纳米复合材料（MoSe-rGO/SPCE），用于伏安法同时检测阿米替林和卡马西平。采用场发射扫描电子显微镜（FE-SEM）、能谱（EDX）、X 射线衍射（XRD）和傅里叶变换红外光谱（FT-IR）等多种技术对 MoSe-rGO 纳米复合材料的形貌和结构进行了表征。此外，还利用计时安培法、差分脉冲伏安法（DPV）和线性扫描伏安法（LSV）对阿米替林的电化学氧化进行了研究。数据显示，MoSe-rGO/SPCE 对阿米替林具有很高的电流灵敏度。MoSe-rGO/SPCE 上阿米替林氧化的峰电流具有线性动态范围（0.02-380.0 μM）和较窄的检测限（0.007 μM）。MoSe-rGO/SPCE 成功地用于检测实际样品中的卡马西平和阿米替林，回收率较高。
