Fradkin S Z, Zhavrid E A, Nebyshinskaia N S, Istomin Iu P
Eksp Onkol. 1987;9(3):64-8, 77.
The injection of sarcolysine, methotrexate, thiophosphamide, cyclophosphamide, adryamycin and platidinum during glucose infusion is shown to increase their antitumour activity. The antitumour effectiveness of 5-FU did not increase under conditions of artificial hyperglycemia, while that of vincristine decreased. Intensification of the activity of some chemotherapeutic drugs in combination with hyperglycemia was observed against the background of their increased general toxic effects.
在葡萄糖输注期间注射溶肉瘤素、甲氨蝶呤、硫磷酰胺、环磷酰胺、阿霉素和顺铂，可提高它们的抗肿瘤活性。在人工高血糖条件下，5-氟尿嘧啶的抗肿瘤效力并未增加，而长春新碱的效力则降低。在一些化疗药物总体毒性作用增加的背景下，观察到它们与高血糖联合使用时活性增强。
