用于了解药物毒性机制的组学技术。

Omics technologies to understand drug toxicity mechanisms.

作者信息

Nguyen Nhan, Jennen Danyel, Kleinjans Jos

机构信息

Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, Maastricht 6229ER, the Netherlands.

出版信息

Drug Discov Today. 2022 Nov;27(11):103348. doi: 10.1016/j.drudis.2022.103348. Epub 2022 Sep 8.

DOI:10.1016/j.drudis.2022.103348

PMID:36089240

Abstract

Drug side effects are an important study subject in pharmacology. Recent omics technologies provide a range of omics data and help to understand the biological mechanisms involved in drug effects. These modern technologies provide significant support to all biological disciplines, including drug toxicology. In this review, we provide an overview the use of omics applications to understand drug side effects at the molecular level. We discuss by available omics technologies, their possible uses, as well as their advantages and limitations.

摘要

药物副作用是药理学中的一个重要研究课题。近期的组学技术提供了一系列组学数据，并有助于理解药物作用所涉及的生物学机制。这些现代技术为包括药物毒理学在内的所有生物学学科提供了重要支持。在本综述中，我们概述了组学应用在分子水平上理解药物副作用方面的用途。我们讨论了现有的组学技术、它们的可能用途以及它们的优缺点。