Jensen L S, Krarup N, Juhl C, Nielsen T H, Larsen J A
Endoscopy. 1987 May;19(3):96-100. doi: 10.1055/s-2007-1018251.
In an experimental animal model with portal hypertension and esophageal varices, endoscopic sclerotherapy of the varices with Aethoxysclerol was compared with selective embolisation of the coronary vein with absolute ethanol. After 4 courses of endoscopic sclerotherapy the varices were permanently obliterated, as documented by portography and endoscopy. Selective embolisation also caused obliteration of the coronary vein and varices, but early and repeated recanalisation occurred, and permanent obliteration was only obtained when embolisation was combined with endoscopic sclerotherapy. Portal vein thrombosis occurred when embolisation was repeated more than 3 times. Hepatic blood flow was significantly higher in animals treated by endoscopic sclerotherapy than in nontreated controls and animals treated by selective embolisation alone.
在一个患有门静脉高压和食管静脉曲张的实验动物模型中，将用乙氧硬化醇进行内镜下静脉曲张硬化疗法与用无水乙醇进行冠状静脉选择性栓塞术进行了比较。经过4个疗程的内镜下硬化疗法后，门静脉造影和内镜检查证明静脉曲张被永久性闭塞。选择性栓塞术也导致冠状静脉和静脉曲张闭塞，但早期和反复再通发生，只有当栓塞术与内镜下硬化疗法联合使用时才获得永久性闭塞。当栓塞术重复超过3次时发生门静脉血栓形成。接受内镜下硬化疗法治疗的动物的肝血流量显著高于未治疗的对照组和仅接受选择性栓塞术治疗的动物。
