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新霉素从马子宫的吸收:发情周期阶段和载体体积的影响。

Absorption of neomycin from the equine uterus: effect of stage of oestrous cycle and volume of vehicle.

作者信息

Boyd E H, Allen W E

出版信息

Equine Vet J. 1987 May;19(3):195-7. doi: 10.1111/j.2042-3306.1987.tb01377.x.

DOI:10.1111/j.2042-3306.1987.tb01377.x
PMID:3608955
Abstract

Plasma concentrations of neomycin were measured following intrauterine infusion of 3.3 mg/kg bodyweight neomycin sulphate. Mares in oestrus absorbed approximately 6 per cent of neomycin infused whereas mares in a luteal phase absorbed 56 per cent. The volume of infusate also affected absorption as increased volume resulted in decreased absorption. The decreased absorption both during oestrus and when large volumes were used was probably due to reflux of antibiotic through the cervix.

摘要

在子宫内注入3.3毫克/千克体重的硫酸新霉素后,测定了血浆中新霉素的浓度。发情期的母马吸收了注入新霉素的约6%,而处于黄体期的母马吸收了56%。注入液的体积也影响吸收,因为体积增加会导致吸收减少。发情期以及使用大量注入液时吸收减少,可能是由于抗生素通过子宫颈回流所致。

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