Boyd E H, Allen W E
Department of Surgery and Obstetrics, Royal Veterinary College, North Mymms, Hertfordshire.
Vet Rec. 1988 Jan 9;122(2):37-9. doi: 10.1136/vr.122.2.37.
Plasma concentrations of neomycin were measured after intrauterine infusion of 3.3 mg/kg neomycin sulphate. Mares infected two hours previously with an intra-uterine infusion of beta-haemolytic streptococci absorbed approximately 12 per cent of the neomycin in both the oestrous and the luteal phases of the cycle. Normal mares in oestrus absorbed 6 per cent of the neomycin infused and luteal mares absorbed 56 per cent. In infected mares the peak plasma concentrations occurred two hours after neomycin infusion, earlier than in healthy mares. Cervical flushings after neomycin infusion in infected luteal mares revealed an increased reflux of neomycin when compared with healthy mares. Prior infusion of 30 ml of 10 per cent Lugol's iodine into the uterus resulted in 31 per cent of neomycin being absorbed by oestrous mares and 64 per cent by mares in the luteal phase. Peak plasma concentrations occurred 30 minutes after infusion in both phases. In the luteal phase the mares' absorption of neomycin may have been maximal.
在子宫内注入3.3毫克/千克硫酸新霉素后，测量血浆中新霉素的浓度。两小时前经子宫内注入β-溶血性链球菌感染的母马，在发情期和黄体期吸收的新霉素约为注入量的12%。发情期的正常母马吸收注入新霉素的6%，黄体期母马吸收56%。感染母马在注入新霉素后两小时出现血浆浓度峰值，比健康母马出现峰值的时间早。与健康母马相比，感染黄体期母马注入新霉素后子宫颈冲洗液中新霉素的反流增加。预先向子宫内注入30毫升10%的卢戈氏碘，发情期母马吸收31%的新霉素，黄体期母马吸收64%。两个阶段注入后30分钟出现血浆浓度峰值。在黄体期，母马对新霉素的吸收可能已达到最大值。
