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资源匮乏地区小儿急性烧伤液体复苏的实用公式:一项试点研究。

A practical formula for fluid resuscitation in acute paediatric burns in a low resource setting: A pilot study.

作者信息

Allorto N L, Wall S L

机构信息

Greys Hospital, Department of Surgery, Pietermaritzburg Metropolitan, KwaZulu Natal, South Africa; University of KwaZulu Natal, KwaZulu Natal, South Africa.

Edendale Hospital, Department of Surgery, Pietermaritzburg Metropolitan, KwaZulu Natal, South Africa; University of KwaZulu Natal, KwaZulu Natal, South Africa.

出版信息

Injury. 2023 Jan;54(1):25-28. doi: 10.1016/j.injury.2022.08.058. Epub 2022 Aug 24.

DOI:10.1016/j.injury.2022.08.058
PMID:36089555
Abstract

BACKGROUND

Appropriate fluid resuscitation of acute burn injury is critical and there are recognized challenges with fluid resuscitation, including those with relevance to low resource settings. We developed a practical protocol that guides burn resuscitation and sought to evaluate the safety of our modified resuscitation formula through a small pilot study that particularly addresses the problems we have experienced in a low resource setting.

METHODS

Children with burns more than 15% total body surface area admitted within 24 h of injury to Edendale Hospital between 1 June 2021 and 31 August 2021 were included. The resuscitation formula used was 2 mls of Ringers Lactate per bodyweight in kilograms per% total body surface area (TBSA) given over 24 h and adjusted according to urine output. Data analysed included age, weight, mechanism, TBSA, hours post burn at presentation to hospital, total fluid given in the first 24 h of admission, total urine output in the first 24 h of admission, number of fluid adjustments made during the first 24 h and complications related to fluid resuscitation.

RESULTS

Ten children were included. The median age was 3 (IQR 2-5) years old, with a mean weight of 14.9 (SD 5.07) kilograms, a median TBSA of 17.4 (IQR 16-26)%, presenting at a median of 12 (6.5-18) hours post burn injury. Mechanism of burn was scald in all cases, with 9 being hot water and hot food in one. In the first 24 h a mean of 2.05 (SD 0.58) mls/kg of fluid was received with a mean urine output of 1.66 (SD 0.57) mls/kg/hr.

CONCLUSION

The results of this pilot study to evaluate the safety of our protocol seem reasonable. It is limited by the lack of larger injuries as well as adult patients and a larger prospective study is pertinent.

摘要

背景

急性烧伤损伤的适当液体复苏至关重要,并且液体复苏存在公认的挑战,包括与资源匮乏地区相关的挑战。我们制定了一个指导烧伤复苏的实用方案,并试图通过一项小型试点研究评估我们改良复苏公式的安全性,该研究特别针对我们在资源匮乏地区遇到的问题。

方法

纳入2021年6月1日至2021年8月31日期间在埃登代尔医院受伤后24小时内入院、烧伤总面积超过15%的儿童。使用的复苏公式是每24小时按每千克体重每%烧伤总面积给予2毫升乳酸林格氏液,并根据尿量进行调整。分析的数据包括年龄、体重、致伤机制、烧伤总面积、入院时烧伤后的小时数、入院后第一个24小时内给予的总液体量、入院后第一个24小时内的总尿量、第一个24小时内进行的液体调整次数以及与液体复苏相关的并发症。

结果

纳入了10名儿童。中位年龄为3岁(四分位间距2 - 5岁),平均体重为14.9千克(标准差5.07),中位烧伤总面积为17.4%(四分位间距16 - 26%),烧伤后中位12小时(6.5 - 18小时)入院。所有病例的烧伤机制均为烫伤,其中9例为热水烫伤,1例为热食物烫伤。在第一个24小时内,平均每千克体重接受2.05毫升(标准差0.58)的液体,平均尿量为1.66毫升/千克/小时(标准差0.57)。

结论

这项评估我们方案安全性的试点研究结果似乎合理。它受到缺乏更严重损伤病例以及成年患者的限制,因此进行更大规模的前瞻性研究是有必要的。

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