膳食纤维摄入量与结直肠癌风险的关联：PrebiotiCa 研究。

Association of prebiotic fiber intake with colorectal cancer risk: the PrebiotiCa study.

机构信息

Unit of Medical Statistics and Biometry, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.

出版信息

Eur J Nutr. 2023 Feb;62(1):455-464. doi: 10.1007/s00394-022-02984-y. Epub 2022 Sep 11.

DOI:10.1007/s00394-022-02984-y

PMID:36089645

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9899730/

Abstract

PURPOSE

To evaluate the association between the intake of specific fibers with prebiotic activity, namely inulin-type fructans (ITFs), fructooligosaccharides (FOSs) and galactooligosaccharides (GOSs), and colorectal cancer risk.

METHODS

Within the PrebiotiCa study, we used data from a multicentric case-control study conducted in Italy and including 1953 incident, histologically confirmed, colorectal cancer patients and 4154 hospital controls. The amount of six prebiotic molecules [ITFs, nystose (FOS), kestose (FOS), 1F-β-fructofuranosylnystose (FOS), raffinose (GOS) and stachyose (GOS)] in a variety of foods was quantified via laboratory analyses. Subjects' prebiotic fiber intake was estimated by multiplying food frequency questionnaire intake by the prebiotic content of each food item. The odds ratios (OR) of colorectal cancer for quintiles of intakes were derived from logistic regression models including terms for major confounders and total energy intake.

RESULTS

GOSs intake was inversely associated with colorectal cancer risk. The OR for the highest versus the lowest quintile of intake were 0.73 (95% confidence interval, CI 0.58-0.92) for raffinose and 0.64 (95% CI 0.53-0.77) for stachyose, with significant inverse trends across quintiles. No association was found with total ITFs and FOSs. The association with stachyose was stronger for colon (continuous OR = 0.74, 95% CI 0.66-0.83) than rectal cancer (OR = 0.89, 95% CI 0.79-1.02).

CONCLUSION

Colorectal cancer risk was inversely associated with the intake of dietary GOSs, but not ITFs and FOSs.

摘要

目的

评估具有益生元活性的特定纤维（即菊粉型果聚糖（ITF）、低聚果糖（FOS）和低聚半乳糖（GOS））的摄入量与结直肠癌风险之间的关联。

方法

在 PrebiotiCa 研究中，我们使用了在意大利进行的一项多中心病例对照研究的数据，该研究纳入了 1953 例经组织学证实的结直肠癌新发病例和 4154 例医院对照。通过实验室分析定量了六种益生元分子[ITF、棉子糖（FOS）、密二糖（FOS）、1F-β-果呋喃果糖基棉子糖（FOS）、棉子糖（GOS）和水苏糖（GOS）]在各种食物中的含量。通过食物频率问卷摄入量乘以每种食物的益生元含量来估计受试者的益生元纤维摄入量。通过包括主要混杂因素和总能量摄入的逻辑回归模型得出摄入量五分位数的结直肠癌比值比（OR）。

结果

GOS 摄入量与结直肠癌风险呈负相关。最高五分位数与最低五分位数的 OR 分别为棉子糖摄入的 0.73（95%置信区间，CI 0.58-0.92）和水苏糖摄入的 0.64（95% CI 0.53-0.77），且五分位数之间存在显著的负相关趋势。与总 ITF 和 FOS 无关联。与直肠相比，水苏糖与结肠癌的相关性更强（连续 OR=0.74，95% CI 0.66-0.83）（OR=0.89，95% CI 0.79-1.02）。