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头颈部放疗前的牙科管理:4 年单中心经验。

Dental management before radiotherapy of the head and neck region: 4-year single-center experience.

机构信息

Department of Conservative Dentistry and Periodontology, University Hospital, LMU Munich, Munich, Germany.

Department of Orthodontics and Dentofacial Orthopedics, University Hospital, LMU Munich, Munich, Germany.

出版信息

Clin Exp Dent Res. 2022 Dec;8(6):1478-1486. doi: 10.1002/cre2.662. Epub 2022 Sep 11.

DOI:10.1002/cre2.662
PMID:36089654
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9760134/
Abstract

OBJECTIVE

To review our experience with a standardized dental management approach in patients with planned radiotherapy of the head and neck region based on preradiation and follow-up data.

MATERIAL AND METHODS

Records of patients who underwent radiotherapy between June 2016 and November 2020 were reviewed. Data on dental findings and therapeutic recommendations were extracted from a prospectively managed database. Hospital records were used to obtain follow-up data.

RESULTS

Two hundred eighty-one patient records were identified. After the exclusion of 81 patients because of incomplete data, 200 patients were included in the study. Dental findings relevant to radiotherapy were found in 144 cases (72.0%). Teeth extractions were recommended in 112 (56.0%) patients. Follow-up data were available for 172 (86.0%) patients (mean follow-up: 16.8 ± 10.7 months). Radiodermatitis was the most frequently observed sequela of radiotherapy (42.4%), followed by dysphagia (38.4%) and stomatitis (36.6%). Osteoradionecrosis was observed in only 2.3% of the patients.

CONCLUSION

Dental findings relevant to planned radiotherapy were frequent and in many cases resulted in recommendations for teeth extraction. Based on our standardized dental management protocol, we observed low rates of late oral complications after radiotherapy of the head and neck region.

摘要

目的

根据放疗前和随访数据,回顾我们采用标准化牙科管理方法治疗计划行头颈部放疗患者的经验。

材料与方法

回顾了 2016 年 6 月至 2020 年 11 月期间接受放疗的患者的病历。从一个前瞻性管理的数据库中提取了有关牙科发现和治疗建议的数据。利用医院记录获得随访数据。

结果

确定了 281 份患者病历。排除了 81 份因数据不完整而无法纳入的患者后,共有 200 名患者纳入研究。144 例(72.0%)患者存在与放疗相关的牙科发现。112 例(56.0%)患者被建议拔牙。172 例(86.0%)患者可获得随访数据(平均随访时间:16.8±10.7 个月)。放射性皮炎是放疗最常见的后遗症(42.4%),其次是吞咽困难(38.4%)和口炎(36.6%)。仅 2.3%的患者发生了骨放射性坏死。

结论

计划行放疗的患者常存在与牙科相关的发现,且这些发现常导致拔牙建议。根据我们的标准化牙科管理方案,我们观察到头颈部放疗后晚期口腔并发症的发生率较低。

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Clin Oral Investig. 2022 Mar;26(3):2937-2948. doi: 10.1007/s00784-021-04276-x. Epub 2021 Nov 18.
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Radiation therapy-associated toxicity: Etiology, management, and prevention.放射治疗相关性毒性:病因、处理和预防。
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Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma.头颈部鳞状细胞癌患者颌骨放射性骨坏死的危险因素。
Radiat Oncol. 2021 Jan 5;16(1):1. doi: 10.1186/s13014-020-01701-5.
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Late side effects of radiation treatment for head and neck cancer.头颈部癌放射治疗的晚期副作用。
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Pre-radiotherapy dental extractions in patients with head and neck cancer: a Delphi study.头颈部癌症患者放疗前的拔牙:一项德尔菲研究。
J Dent. 2020 Jun;97:103350. doi: 10.1016/j.jdent.2020.103350. Epub 2020 May 1.
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