Bonizzi Giuseppina, Zattoni Lorenzo, Capra Maria, Cassi Cristina, Taliento Giulio, Ivanova Mariia, Guerini-Rocco Elena, Fumagalli Marzia, Monturano Massimo, Albini Adriana, Viale Giuseppe, Orecchia Roberto, Fusco Nicola
Biobank for Translational and Digital Medicine, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Front Mol Biosci. 2022 Aug 26;9:967310. doi: 10.3389/fmolb.2022.967310. eCollection 2022.
Biobanks are biorepositories that collect, process, store, catalog, and distribute human biological samples, and record the associated data. The role and action field of these strategic infrastructures for implementing precision medicine in translational research is continuously evolving. To ensure the optimal quality at all stages of biobanking, specific protocols are required and should be elaborated according to updated guidelines, recommendations, laws, and rules. This article illustrates the standard operating procedures, including protocols, troubleshooting, and quality controls, of a fully certified biobank in a referral Cancer Center. This model involves all clinical departments and research groups to support the dual mission of academic cancer centers, i.e. to provide high-quality care and high-quality research. All biobanking activities based on the type of biological specimens are detailed and the most tricky methodological aspects are discussed, from patients' informed consent to specimen management.
生物样本库是收集、处理、储存、编目和分发人类生物样本，并记录相关数据的生物储存库。这些战略基础设施在转化研究中实施精准医学的作用和行动领域正在不断发展。为确保生物样本库所有阶段的最佳质量，需要特定的方案，并应根据最新的指南、建议、法律和规则进行制定。本文阐述了一家转诊癌症中心的完全认证生物样本库的标准操作程序，包括方案、故障排除和质量控制。该模式涉及所有临床科室和研究小组，以支持学术癌症中心的双重使命，即提供高质量的医疗服务和高质量的研究。基于生物标本类型的所有生物样本库活动都有详细说明，并讨论了从患者知情同意到标本管理等最棘手的方法学问题。
