Nell Erica-Mari, Abdullah Ibtisam, Griesel Carla, Subramony Nadhiya, du Pisani Louis Almero, Chapanduka Zivanai Cuthbert
Division of Haematological Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.
J Cancer Epidemiol. 2022 Aug 31;2022:2058280. doi: 10.1155/2022/2058280. eCollection 2022.
Adult T-cell leukaemia/lymphoma (ATLL) is a rare and aggressive malignancy of mature T-cells. Limited epidemiological studies have shown that there is substantial variation in age at diagnosis and subtype distribution between different geographical regions. This is the first epidemiological study of ATLL in South Africa.
A national epidemiological study of ATLL in South Africa was performed. All new cases of ATLL from 2009 to 2019 were identified by laboratory database search in public and private health care sectors. Demographic and diagnostic data were obtained, and the cases were subtyped according to the Shimoyama classification.
There were 31 patients with ATLL over the 10-year period, with an incidence of 0.06 per 100000 population. The male to female ratio was 1 : 1 and the median age at diagnosis was 37 years. Acute ATLL was the most commonly seen subtype in South Africa.
In this, the first epidemiological study of ATLL in South Africa, we demonstrate that ATLL is a rare disease, that acute ATLL is the most commonly diagnosed subtype, and that ATLL is likely under diagnosed. Patients present at a considerably younger age than the reported age in other nations.
成人T细胞白血病/淋巴瘤（ATLL）是一种罕见的侵袭性成熟T细胞恶性肿瘤。有限的流行病学研究表明，不同地理区域的诊断年龄和亚型分布存在很大差异。这是南非首次对ATLL进行的流行病学研究。
对南非的ATLL进行了一项全国性流行病学研究。通过在公共和私营医疗部门的实验室数据库搜索，确定了2009年至2019年所有新的ATLL病例。获取了人口统计学和诊断数据，并根据岛山分类法对病例进行了亚型分类。
在这10年期间，有31例ATLL患者，发病率为每10万人0.06例。男女比例为1∶1，诊断时的中位年龄为37岁。急性ATLL是南非最常见的亚型。
在这项南非首次对ATLL进行的流行病学研究中，我们证明ATLL是一种罕见疾病，急性ATLL是最常诊断出的亚型，并且ATLL可能诊断不足。患者就诊时的年龄比其他国家报告的年龄要小得多。
