Godini Rasoul, Fallahi Hossein, Pocock Roger
Development and Stem Cells Program, Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
Department of Biology, School of Sciences, Razi University, Kermanshah, Iran.
Front Mol Neurosci. 2022 Aug 25;15:974208. doi: 10.3389/fnmol.2022.974208. eCollection 2022.
Neuronal communication requires precise connectivity of neurite projections (axons and dendrites). Developing neurites express cell-surface receptors that interpret extracellular cues to enable correct guidance toward, and connection with, target cells. Spatiotemporal regulation of neurite guidance molecule expression by transcription factors (TFs) is critical for nervous system development and function. Here, we review how neurite development is regulated by TFs in the nervous system. By collecting publicly available transcriptome and ChIP-sequencing data, we reveal gene expression dynamics during neurite development, providing insight into transcriptional mechanisms governing construction of the nervous system architecture.
神经元通讯需要神经突投射（轴突和树突）的精确连接。正在发育的神经突表达细胞表面受体，这些受体解读细胞外信号，以实现向靶细胞的正确导向并与之连接。转录因子对神经突导向分子表达的时空调节对于神经系统的发育和功能至关重要。在这里，我们综述了转录因子如何在神经系统中调节神经突发育。通过收集公开可用的转录组和染色质免疫沉淀测序数据，我们揭示了神经突发育过程中的基因表达动态，为控制神经系统结构构建的转录机制提供了见解。
