非典型转化生长因子-β信号传导调控……中的神经元导向

Atypical TGF-β signaling controls neuronal guidance in .

作者信息

Baltaci Oguzhan, Pedersen Mikael Egebjerg, Sherry Tessa, Handley Ava, Snieckute Goda, Cao Wei, Haas Matilda, Archer Stuart, Pocock Roger

机构信息

Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia.

Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark.

出版信息

iScience. 2022 Jan 18;25(2):103791. doi: 10.1016/j.isci.2022.103791. eCollection 2022 Feb 18.

Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.